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Merck
CN

396265

Bis(2-carboxyethylgermanium(IV) sesquioxide)

99%

Synonym(s):

GE 132

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About This Item

Linear Formula:
O[Ge(=O)CH2CH2CO2H]2
CAS Number:
Molecular Weight:
339.42
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352103
EC Number:
235-800-0
MDL number:
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InChI key

XEABSBMNTNXEJM-UHFFFAOYSA-N

InChI

1S/C6H10Ge2O7/c9-5(10)1-3-7(13)15-8(14)4-2-6(11)12/h1-4H2,(H,9,10)(H,11,12)

SMILES string

OC(=O)CC[Ge](=O)O[Ge](=O)CCC(O)=O

assay

99%

form

solid

functional group

carboxylic acid

Quality Level

General description

Bis(2-carboxyethylgermanium(IV) sesquioxide), also known as repagermanium, is a water-soluble organogermanium compound that exhibits immunostimulatory properties. It is also used as an ingredient in food and cosmetics.

Application

Bis(2-carboxyethylgermanium(IV) sesquioxide) can be used as a precursor in the preparation of photoluminescent carbon dots, applicable as fluorescent probes in bioimaging applications.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Petra Mulder et al.
PloS one, 12(1), e0169740-e0169740 (2017-01-12)
Obese patients with chronic inflammation in white adipose tissue (WAT) have an increased risk of developing non-alcoholic steatohepatitis (NASH). The C-C chemokine receptor-2 (CCR2) has a crucial role in the recruitment of immune cells to WAT and liver, thereby promoting
Yun Huan Yuan et al.
Nanoscale, 7(40), 16841-16847 (2015-09-26)
Carbon dots doped with germanium (GeCDs) were firstly prepared by a new simple 15 min carbonation synthesis route, exhibiting excitation-independent photoluminescence (PL), which could avoid autofluorescence in bioimaging applications. The as-prepared GeCDs have low cell toxicity, good biocompatibility, high intracellular
Yukinori Tamura et al.
Arteriosclerosis, thrombosis, and vascular biology, 28(12), 2195-2201 (2008-09-27)
Recently, adipose tissue inflammation induced by macrophage infiltration through MCP-1/C-C chemokine receptor-2 (CCR2) pathway is considered to play a role in the development of visceral obesity and insulin resistance. In the present study, to further examine the role of CCR2
Bonnie J Kaplan et al.
Journal of alternative and complementary medicine (New York, N.Y.), 10(2), 337-344 (2004-05-29)
This paper reviews the history, chemistry, safety, toxicity, and anticancer effects of the organogermanium compound bis (2-carboxyethylgermanium) sesquioxide (CEGS). A companion review follows, discussing the inaccuracies in the scientific record that have prematurely terminated research on clinical uses of CEGS.
Takashi Nakamura et al.
Bioscience, biotechnology, and biochemistry, 76(2), 375-377 (2012-02-09)
The organic germanium compound, Ge-132, has immune-modulating effects. We evaluated the symbiotic effects of Ge-132 with lactobacilli and oligosaccharide (LB/OS) on the immune responses of mice. The highest fecal IgA levels were observed in the mice receiving a low concentration

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