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(2-Hydroxypropyl)-γ-cyclodextrin

Name: (2-Hydroxypropyl)-γ-cyclodextrin
Brand: ALDRICH

extent of labeling: 0.6 molar substitution

Synonym(s):

HP-γ-CD, HPGCD, HGC

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About This Item

CAS Number:

128446-34-4

UNSPSC Code:

12352201

NACRES:

NA.22

form

powder

Quality Level

100

optical activity

[α]20/D +145°, c = 1 in H₂O

mol wt

average M_w ~1,580

extent of labeling

0.6 molar substitution

InChI

1S/C51H88O38/c1-14(56)8-73-11-21-42-29(64)36(71)50(81-21)85-40-19(6-54)79-48(34(69)27(40)62)89-44-23(13-75-10-16(3)58)82-51(37(72)30(44)65)86-41-20(7-55)78-47(33(68)26(41)61)88-43-22(12-74-9-15(2)57)80-49(35(70)28(43)63)84-39-18(5-53)76-45(31(66)24(39)59)83-38-17(4-52)77-46(87-42)32(67)25(38)60/h14-72H,4-13H2,1-3H3/t14?,15?,16?,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-/m0/s1

InChI key

ODLHGICHYURWBS-RYJYQAAZSA-N

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General description

(2-Hydroxypropyl)-γ-cyclodextrin belongs to the class of cyclodextrin derivatives, which exhibit a greater extent of solubility in water compared to their parent compounds. It is widely used in parenteral formulations and solid dosage forms to aid in the improvement of their stability, dissolution, bioavailability, etc.

Application

(2-Hydroxypropyl)-γ-cyclodextrin may be used:

As a mobile phase additive in the study of the host-guest interaction with organic low molecular mass compounds prior to their quantification using reversed phase-high performance liquid chromatography (RP-HPLC) technique.
As a chiral surfactant for the analysis of econazole by micellar electrokinetic chromatography (MEKC).
As an analytical standard for the determination of the analyte in biological samples by HPLC.
As a chiral selector for the identification of propiconazole by MEKC.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Proceedings of the Ninth International Symposium on Cyclodextrins: Santiago de Compostela, Spain, May 31?June 3, 1998

Proceedings of the Ninth International Symposium on Cyclodextrins (2012)

Chiral separation of econazole using micellar electrokinetic chromatography with hydroxypropyl-gamma-cyclodextrin

Hermawan D, et al.

Journal of Pharmaceutical and Biomedical Analysis, 53(5), 1244-1249 (2010)

On-line preconcentration and chiral separation of propiconazole by cyclodextrin-modified micellar electrokinetic chromatography.

Wan Aini Wan Ibrahim et al.

Journal of chromatography. A, 1170(1-2), 107-113 (2007-10-05)

A method for the chiral separation of propiconazole using cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC) with hydroxypropyl-gamma-cyclodextrin (HP-gamma-CD) as chiral selector is reported. The use of a mixture of 30 mM HP-gamma-CD, 50mM SDS, methanol-acetonitrile 10%:5% (v/v) in 25 mM phosphate

High-performance liquid chromatographic determination of 2-hydroxypropyl-gamma-cyclodextrin in different biological fluids based on cyclodextrin enhanced fluorescence

Szeman J, et al.

Journal of Chromatography. B, Biomedical Applications, 774(2), 157-164 (2002)

Interaction of native alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin and their hydroxypropyl derivatives with selected organic low molecular mass compounds at elevated and subambient temperature under RP-HPLC conditions.

P K Zarzycki et al.

Analytical and bioanalytical chemistry, 391(8), 2793-2801 (2008-06-20)

The main focus of this study was to explore the capability of native alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin and their hydroxypropyl derivatives for host-guest interaction with 7,8-dimethoxyflavone, selected steroids (estetrol, estriol, estradiol, estrone, testosterone, cortisone, hydrocortisone, progesterone and 17alpha-hydroxyprogesterone) and polycyclic

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