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Merck
CN

38827

4,4′-Dimethoxytriphenylmethyl chloride

≥97.0% (HPLC)

Synonym(s):

4,4′-Dimethoxytrityl chloride, Chloro-4,4′-dimethoxytriphenylmethane, DMT, DMT-Cl

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About This Item

Empirical Formula (Hill Notation):
C21H19ClO2
CAS Number:
40615-36-9
Molecular Weight:
338.83
UNSPSC Code:
12352101
NACRES:
NA.22
PubChem Substance ID:
57649867
EC Number:
255-002-6
Beilstein/REAXYS Number:
2471942
MDL number:
MFCD00008409

Key Documents

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Product Name

4,4′-Dimethoxytriphenylmethyl chloride, ≥97.0% (HPLC)

InChI key

JBWYRBLDOOOJEU-UHFFFAOYSA-N

InChI

1S/C21H19ClO2/c1-23-19-12-8-17(9-13-19)21(22,16-6-4-3-5-7-16)18-10-14-20(24-2)15-11-18/h3-15H,1-2H3

SMILES string

COc1ccc(cc1)C(Cl)(c2ccccc2)c3ccc(OC)cc3

assay

≥97.0% (HPLC)

mp

123-125 °C

functional group

chloro
phenyl

Quality Level

200

Gene Information

human ... HTR2A(3356), HTR2B(3357), HTR2C(3358)
rat ... Htr1a(24473), Htr2a(29595)

Related Categories

Application

4,4′-Dimethoxytriphenylmethyl chloride (DMTrCl) can be used as a protecting agent:
  • For hydroxyl group of nucleosides/nucleotides as its O-(4,4′-dimethoxytrityl)derivative.
  • For 10 sulfhydryl group of oligonucleotide analogs as its DMTr thioether.

Other Notes

Useful protecting-group reagent; Removal

signalword

Danger

Hazard Classifications

Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

8B - Non-combustible corrosive hazardous materials

wgk

WGK 3

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ1645
BCBW4855
BCBJ8463V
1442828V
1442828

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M.P. Reddy et al.
Tetrahedron Letters, 28, 23-23 (1987)
Selective protection and deprotection procedures for thiol and hydroxyl groups
Huang Z and Benner SA
Synlett, 1993(01), 83-84 (1993)
V. Amarnath et al.
Chemical Reviews, 77, 183-183 (1977)
A novel entry to 2′-O-aminopropyl modified nucleosides amenable for further modifications
Haas J and Engels JW
Tetrahedron Letters, 48(50), 8891-8894 (2007)
M.D. Matteucci et al.
Tetrahedron Letters, 81, 3243-3243 (1980)
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