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376914

Sigma-Aldrich

Poly(methyl methacrylate-co-methacrylic acid)

average Mw ~34,000 by GPC, average Mn ~15,000 by GPC

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Synonym(s):
Poly(methacrylic acid-co-methyl methacrylate)
CAS Number:
25086-15-1
MDL number:
MFCD00243185
UNSPSC Code:
12162002
PubChem Substance ID:
24863477
NACRES:
NA.23

feed ratio

1:0.016 (methyl methacrylate:methacrylic acid)

mol wt

average Mn ~15,000 by GPC
average Mw ~34,000 by GPC

inherent viscosity

0.19 dL/g(lit.)

transition temp

Tg 105 °C

InChI

1S/C5H8O2.C4H6O2/c1-4(2)5(6)7-3;1-3(2)4(5)6/h1H2,2-3H3;1H2,2H3,(H,5,6)

InChI key

IWVKTOUOPHGZRX-UHFFFAOYSA-N

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Application

  • Ultrafine Nanoparticles of Poly(Methyl Methacrylate-co-Methacrylic Acid) Loaded with Aspirin: This study focuses on the preparation and potential therapeutic applications of biocompatible nanoparticles loaded with aspirin, highlighting their suitability for medical use (López-Muñoz et al., 2019).
  • Biocompatible and biodegradable ultrafine nanoparticles of poly (methyl methacrylate-co-methacrylic acid) prepared via semicontinuous heterophase: Discusses the synthesis of biodegradable nanoparticles for potential biomedical applications, emphasizing their eco-friendly nature and suitability for drug delivery systems (Saade et al., 2016).
  • Synthesis and characteristics of poly(methyl methacrylate‐co‐methacrylic acid)/poly(methacrylic acid‐co‐N‐isopropylacrylamide) thermosensitive semi‐hollow latex: Explores the unique properties of thermosensitive latex particles for advanced material applications, potentially useful in smart drug delivery systems (Lee et al., 2014).
  • Preparation and release behavior of poly(methyl methacrylate-co-methacrylic acid)-based electrospun nanofibrous mats loaded with doxorubicin: Examines the use of polymeric nanofibers for controlled drug release, particularly for cancer treatment, demonstrating the versatility of poly(methyl methacrylate-co-methacrylic acid) in pharmaceutical applications (López-Muñoz et al., 2023).

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Katia P Seremeta et al.
Colloids and surfaces. B, Biointerfaces, 102, 441-449 (2012-09-27)
The design of simple and scalable drug delivery systems to target the central nervous system (CNS) could represent a breakthrough in the addressment of the HIV-associated neuropathogenesis. The intranasal (i.n.) route represents a minimally invasive strategy to surpass the blood-brain
Kateřina Dvořáčková et al.
Medicina (Kaunas, Lithuania), 48(4), 192-202 (2012-07-28)
Eudragit® NM was investigated as a matrix former in combination with microcrystalline cellulose as an insoluble filler for preparing controlled-release tablets containing model drugs with different solubility. Three sets of matrix tablets differing in the drug-to-filler ratio (1:1, 2:1, and
Rouslan I Moustafine et al.
International journal of pharmaceutics, 439(1-2), 17-21 (2012-10-09)
Interpolymer interactions between the countercharged methacrylate copolymers Eudragit(®) RL 30D (polycation) and Eudragit(®) FS 30D (polyanion), were investigated in conditions mimicking the gastrointestinal environment. The formation of inter-macromolecular ionic bonds between Eudragit(®) RL 30D and Eudragit(®) FS 30D was investigated
Moorthy Ganeshkumar et al.
Colloids and surfaces. B, Biointerfaces, 103, 238-243 (2012-12-04)
Hollow amphiphilic carbon nanosphere loaded insulin with biodegradable polymer coating (ACP) for oral delivery, was developed to overcome intestinal epithelial barriers and protect insulin from photolytic enzymes. ACP was characterized by laser diffraction spectroscopy for size, distribution and shape by
Yan Zhang et al.
International journal of pharmaceutics, 436(1-2), 341-350 (2012-07-07)
In the present study thiolated Eudragit L100 (Eul) based polymeric nanoparticles (NPs) were employed to develop an oral insulin delivery system. Sulfydryl modification was achieved by grafting cysteine to the carboxylic acid group of Eudragit L100, which displayed maximum conjugate
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