372382
Sodium bicarbonate-13C
98 atom % 13C, 99% (CP)
Synonym(s):
13C Labeled sodium bicarbonate, Sodium hydrogencarbonate-13C
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About This Item
Linear Formula:
NaH13CO3
CAS Number:
Molecular Weight:
85.00
NACRES:
NA.12
PubChem Substance ID:
UNSPSC Code:
51113400
MDL number:
Product Name
Sodium bicarbonate-13C, 98 atom % 13C, 99% (CP)
InChI
1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1/i1+1;
SMILES string
[Na].O[13C](O)=O
InChI key
UIIMBOGNXHQVGW-YTBWXGASSA-M
isotopic purity
98 atom % 13C
assay
99% (CP)
form
white powder
mp
>300 °C (lit.)
mass shift
M+1
storage temp.
room temp
Quality Level
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Application
Sodium bicarbonate-13C can be used:
- As a probe for NMR− and MRI− based pH imaging.
- To predict the reaction mechanism in selective hydrogenation of bicarbonate to formate, catalyzed by a ruthenium(III) complex.
- For 13C labeling of amino acid sample for compound-specific stable isotope analysis (CSIA).
Sodium bicarbonate-13C is used to study the lactate metabolism by using hyperpolarized 13C pH imaging and multiparametric MRI.This reagent can be used as probe in nuclear magnetic resonance spectroscopy studies, which enabled large signal gains for low-toxicity hyperpolarized 13C pH imaging in a phantom and in vivo in a murine model of prostate cancer.
General description
Sodium hydrogencarbonate-13C is isotopically enriched compound of sodium bicarbonate.
Packaging
This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Quantified pH imaging with hyperpolarized 13 C-bicarbonate
Scholz DJ, et al.
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 73(6), 2274-2282 (2015)
Ferdia A Gallagher et al.
NMR in biomedicine, 24(8), 1006-1015 (2011-08-04)
pH is a fundamental physiological parameter that is tightly controlled by endogenous buffers. The acid-base balance is altered in many disease states, such as inflammation, ischemia and cancer. Despite the importance of pH, there are currently no routine methods for
D E Korenchan et al.
Chemical communications (Cambridge, England), 52(14), 3030-3033 (2016-01-23)
A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized (13)C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized (13)C pH imaging in a phantom and in vivo in
Current concepts on hyperpolarized molecules in MRI.
Viale A and Aime S
Current Opinion in Chemical Biology, 14(1), 90-96 (2010)
Magnetic resonance imaging of pH in vivo using hyperpolarized 13 C-labelled bicarbonate.
Gallagher FA, et al.
Nature, 453(7197), 940-940 (2008)
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