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grade
technical grade
form
liquid
refractive index
n20/D 1.544 (lit.)
mp
19-20 °C (lit.)
density
1.137 g/mL at 25 °C (lit.)
SMILES string
ClCCCC(=O)c1ccccc1
InChI
1S/C10H11ClO/c11-8-4-7-10(12)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2
InChI key
GHEFQKHLHFXSBR-UHFFFAOYSA-N
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General description
4-Chlorobutyrophenone is a chloro ketone. Preparation of 4-chlorobutyrophenone is reported.
Application
4-Chlorobutyrophenone may be used in the preparation of silyl enol ether, Z-4-chloro-1-phenyl-1-trimethylsilyloxybut-1-ene. It may be used as starting material in the preparation of 8-arylimidazopyridines.
WGK
WGK 3
Flash Point(F)
closed cup
Flash Point(C)
closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
The Journal of Organic Chemistry, 52, 1863-1863 (1987)
Organic & biomolecular chemistry, 6(7), 1238-1243 (2008-03-26)
Treatment of commercially available MesMgBr with 1,4-dioxane produces the key Mes(2)Mg reagent in situ which then mediates the deprotonation of ketones to deliver trimethylsilyl enol ethers, at readily accessible temperatures and without any nucleophilic addition, in an expedient and high
Neighboring group participation by carbonyl oxygen.
Journal of the American Chemical Society, 87(7), 1515-1521 (1965)
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