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363308

Sigma-Aldrich

Carbostyril 124

99%

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Synonym(s):
7-Amino-4-methyl-2(1H)-quinolinone, 7-Amino-4-methyl-2-hydroxyquinoline
Empirical Formula (Hill Notation):
C10H10N2O
CAS Number:
19840-99-4
Molecular Weight:
174.20
EC Number:
243-363-2
MDL number:
MFCD00134256
UNSPSC Code:
12352103
PubChem Substance ID:
57649472
NACRES:
NA.23

Assay

99%

form

solid

mp

278-280 °C (lit.)

λmax

350 nm

SMILES string

CC1=CC(=O)Nc2cc(N)ccc12

InChI

1S/C10H10N2O/c1-6-4-10(13)12-9-5-7(11)2-3-8(6)9/h2-5H,11H2,1H3,(H,12,13)

InChI key

MJXYFLJHTUSJGU-UHFFFAOYSA-N

General description

Carbostyril 124 (CS124) is a chromophore that can be used as a laser dye for sensitization and optical detection. It acts as an antenna molecule that facilitates the light absorption and enhances fluorescence efficiency.

Application

CS124 can be used in the synthesis of luminescent terbium chelates (LTCs) to develop fluoroimmunoassay for the detection of carcinoembryonic antigen. It can also be used in the development of borane lasers.
Suitable as a laser dye

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Modest effectiveness of carbostyril 124 as a sensitising chromophore in europium and terbium amide complexes based on 1, 4, 7, 10-tetraazacyclododecane.
Parker D and Williams JAG
J. Chem. Soc. Perkin Trans. II, 1581-1586 (1996)
Subnanosecond light pulses from GaAs injection lasers.
Lee T and Roldan R
IEEE Journal of Quantum Electronics, 5(11), 551-552 (1969)
Pinghua Ge et al.
Bioconjugate chemistry, 15(5), 1088-1094 (2004-09-16)
Luminescent lanthanide complexes consisting of a lanthanide-binding chelate and organic-based antenna molecule have unusual emission properties, including millisecond excited state lifetimes and sharply spiked spectra, compared to standard organic fluorophores. We have previously used carbostyril (cs124, 7-amino-4-methyl-2(1H)-quinolinone) as an antenna
A novel homogeneous time-resolved fluoroimmunoassay for carcinoembryonic antigen based on water-soluble quantum dots
Chen Z, et al.
Journal of Fluorescence, 23(4), 649-657 (2013)
G Kokotos et al.
Biological chemistry Hoppe-Seyler, 371(9), 835-840 (1990-09-01)
Sensitive and convenient fluorometric assays for the determination of chymotrypsin have been developed by using the substrates Glt-Leu-Phe-NH-Meq, Glt-Phe-NH-FMeq and Glt-Leu-Phe-NH-FMeq, which have been synthesized utilizing the mixed anhydride method. The amidolytic activity of chymotrypsin was measured by the release
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