361518
1-Hydroxypyrene
98%
Synonym(s):
1-Pyrenol
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About This Item
Empirical Formula (Hill Notation):
C16H10O
CAS Number:
Molecular Weight:
218.25
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
98%
InChI
1S/C16H10O/c17-14-9-7-12-5-4-10-2-1-3-11-6-8-13(14)16(12)15(10)11/h1-9,17H
SMILES string
Oc1ccc2ccc3cccc4ccc1c2c34
InChI key
BIJNHUAPTJVVNQ-UHFFFAOYSA-N
assay
98%
mp
179-182 °C (lit.)
Quality Level
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General description
1-Hydroxypyrene, as a urinary metabolite, is a marker of polycyclic aromatic hydrocarbons (PAH) exposure. 1-Hydroxypyrene is an important biomarker of exposure to pyrene.
Application
1-Hydroxypyrene is suitable for use in following studies:
- To investigate the fast detection and quantification of 1-hydroxypyrene in tissue extracts from Nereis diversicolor exposed to sediment-associated pyrene by a simple fluorometric method.
- To investigate the effects of genetic polymorphisms of the cytochrome P450 1A1 (CYP1A1) and 2E1 (CYP2E1) and glutathione S-transferases mu (GSTM1) and theta (GSTT1) on urinary 1-hydroxypyrene and 2-naphthol levels in aircraft maintenance workers.
- To examine the the PAH exposure of cokery workers in an Estonian oil shale processing plant.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Gustavo Faibischew Prado et al.
The Science of the total environment, 437, 200-208 (2012-09-04)
Non-mechanised sugarcane harvesting preceded by burning exposes workers and the people of neighbouring towns to high concentrations of pollutants. This study was aimed to evaluate the respiratory symptoms, lung function and oxidative stress markers in sugarcane workers and the residents
Tsutomu Shimada et al.
Xenobiotica; the fate of foreign compounds in biological systems, 48(6), 565-575 (2017-06-27)
1. 1-Chloropyrene, one of the major chlorinated polycyclic aromatic hydrocarbon contaminants, was incubated with human cytochrome P450 (P450 or CYP) enzymes including CYP1A1, 1A2, 1B1, 2A6, 2A13, 2B6, 2C9, 2D6, 2E1, 3A4 and 3A5. Catalytic differences in 1-chloropyrene oxidation by polymorphic
Hueiwang Anna Jeng et al.
Journal of hazardous materials, 244-245, 436-443 (2013-01-15)
The objective of the cross-sectional study was to assess whether exposure to polycyclic aromatic hydrocarbons (PAHs) from coke oven emissions contributed to alteration of semen quality and sperm DNA integrity in nonsmoking workers. Nonsmoking coke oven workers from a steel
Jena Webb et al.
International archives of occupational and environmental health, 91(1), 105-115 (2017-09-25)
Polycyclic aromatic hydrocarbons (PAHs) are contaminants with carcinogenic effects but little is known about their presence in environments surrounding oil drilling operations and spills or exposure levels in nearby communities. The objective of this study was to characterize PAH levels
Heiman F L Wertheim et al.
Environmental health : a global access science source, 11, 72-72 (2012-09-28)
Urban air pollution is an increasing health problem, particularly in Asia, where the combustion of fossil fuels has increased rapidly as a result of industrialization and socio-economic development. The adverse health impacts of urban air pollution are well established, but
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