359661
H-Lys(Boc)-OH
≥95%, for peptide synthesis
Synonym(s):
Nε-Boc-L-lysine
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About This Item
Linear Formula:
(CH3)3COCONH(CH2)4CH(NH2)COOH
CAS Number:
Molecular Weight:
246.30
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Beilstein/REAXYS Number:
2417626
Product Name
H-Lys(Boc)-OH, ≥95%
InChI
1S/C11H22N2O4/c1-11(2,3)17-10(16)13-7-5-4-6-8(12)9(14)15/h8H,4-7,12H2,1-3H3,(H,13,16)(H,14,15)/t8-/m0/s1
SMILES string
CC(C)(C)OC(=O)NCCCC[C@H](N)C(O)=O
InChI key
VVQIIIAZJXTLRE-QMMMGPOBSA-N
assay
≥95%
form
powder
optical activity
[α]20/D +18°, c = 1 in acetic acid
reaction suitability
reaction type: solution phase peptide synthesis
mp
250 °C (dec.) (lit.)
application(s)
peptide synthesis
storage temp.
2-8°C
Quality Level
General description
H-Lys(Boc)-OH also known as Nε-Boc-L-lysine, is commonly used in solution phase peptide synthesis.
Application
H-Lys(Boc)-OH can be used to prepare pentafluorophenyl esters which further used to synthesize β-peptides.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Solution phase synthesis of beta-peptides using micro reactors
P Watts
Tetrahedron, 58, 5427-5439 (2002)
Shuqin Han et al.
Carbohydrate polymers, 90(2), 1061-1068 (2012-07-31)
A new third generation amphiphilic glycodendrimer was synthesized from a stearylamide lysine dendrimer by condensation of the oligosaccharide moiety. By stepwise condensation and deprotection of di-boc lysine from a core of stearyl amide lysine, a third-generation stearylamide lysine dendrimer was
Maria Moccia et al.
International journal of pharmaceutics, 397(1-2), 179-183 (2010-07-06)
A novel nucleic acid compaction device based on a positively-charged alpha,epsilon-poly-l-lysine was realized for the first time. The polycationic peptide was obtained by assembling Fmoc and Boc orthogonally protected l-lysine monomers by solid phase synthesis. The route to the novel
April Case et al.
Analytical biochemistry, 338(2), 237-244 (2005-03-05)
Tissue transglutaminase (TGase) is a Ca(2+)-dependent enzyme that catalyzes cross-linking of intracellular proteins through a mechanism that involves isopeptide bond formation between Gln and Lys residues. In addition to its transamidation activity, TGase can bind guanosine 5'-triphosphate (GTP) and does
Xiang Gao et al.
Molecular pharmaceutics, 10(1), 187-198 (2012-12-19)
PEGylated lipopeptide surfactants carrying drug-interactive motifs specific for a peptide-nitroxide antioxidant, JP4-039, were designed and constructed to facilitate the solubilization of this drug candidate as micelles and emulsion nanoparticles. A simple screening process based on the ability that prevents the
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