All Photos(1)
About This Item
Linear Formula:
CH3NHC(=NH)NHNO2
CAS Number:
Molecular Weight:
118.09
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
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form
solid
Quality Level
contains
~25% water
mp
153-155 °C (lit.)
SMILES string
CNC(=N)N[N+]([O-])=O
InChI
1S/C2H6N4O2/c1-4-2(3)5-6(7)8/h1H3,(H3,3,4,5)
InChI key
XCXKNNGWSDYMMS-UHFFFAOYSA-N
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General description
1-Methyl-3-nitroguanidine (MNG) is formed as intermediate during the production of hydroxyl radical during 1-methyl-3-nitro-1-nitrosoguanidine (MNNG) - induced gastric cancer in the xanthine oxidase system. MNG has been referred by the U.S. Air Force Armament Laboratory for use in explosive formulations. MNG is formed during nucleophilic attack by H2O2 on the nitroso nitrogen of MNNG. MNG is non-carcinogenic analog of N-methyl-N′-nitro-N-nitrosoguanidine (direct-acting carcinogen).
Application
1-Methyl-3-nitroguanidine (N-methyl-N′-nitroguanidine) was used in the synthesis of clothianidin hapten.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Sol. 1 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
4.1B - Flammable solid hazardous materials
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Akihisa Abe et al.
Microbiological research, 162(2), 130-138 (2006-03-08)
The viable but nonculturable (VBNC) suppression mutant formed platable cells at low temperature stress after inoculation in artificial seawater (ASW). Suppression subtractive hybridization was used to identify differentially expressed genes among cDNAs of the VBNC suppression mutant and the wild-type
T Mikuni et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 70(3-4), 262-268 (1992-03-01)
We examined hydroxyl free radical (.OH) production in the mixture of H2O2 and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) without exposure to light using the electron spin resonance spin-trapping technique. When the mixtures were protected from exposure to light, .OH was formed at pH
Van Hanh Vu et al.
Journal of microbiology and biotechnology, 20(4), 718-726 (2010-05-15)
A selected fungal strain, for production of the raw-starchdigesting enzyme by solid-state fermentation, was improved by two repeated sequential exposures to gamma-irradiation of Co60, ultraviolet, and four repeated treatments with Nmethyl- N'-nitrosoguanidine. The mutant strain Aspergillus sp. XN15 was chosen
Shuji Ohno et al.
Toxicology letters, 322, 32-38 (2020-01-11)
Neonicotinoids (NNs), a widely used class of systemic pesticides, are regarded as exhibiting selective toxicity in insects. However, NNs are suspected of exerting adverse effects on mammals as well, including humans. To date, only adult male animal models have been
A W Hsie et al.
Molecular toxicology, 1(2-3), 217-234 (1987-04-01)
Previously, we have shown that Chinese hamster ovary (CHO) cells are useful for quantifying chemical-induced gene mutations. We have defined the conditions of a Multiplex CHO System which permits determination of mutagen-induced chromosome aberration, and sister chromatid exchange (SCE) in
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