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Key Documents

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Safety Information

341436

Sigma-Aldrich

Tetramethyl orthosilicate

≥99%

Synonym(s):

Tetramethoxysilane

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About This Item

Linear Formula:
Si(OCH3)4
CAS Number:
681-84-5
Molecular Weight:
152.22
Beilstein:
1699658
EC Number:
211-656-4
MDL number:
MFCD00008341
UNSPSC Code:
12352103
PubChem Substance ID:
24860943
NACRES:
NA.23
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vapor density

5.25 (vs air)

vapor pressure

13 hPa ( 20 °C)

Assay

≥99%

form

liquid

refractive index

n20/D 1.368 (lit.)

bp

121-122 °C (lit.)

mp

−4 °C (lit.)

density

1.023 g/mL at 25 °C (lit.)

SMILES string

CO[Si](OC)(OC)OC

InChI

1S/C4H12O4Si/c1-5-9(6-2,7-3)8-4/h1-4H3

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Show Differences

1 of 4

This Item
21847287682131903
硅酸甲酯 ≥99%

341436

硅酸甲酯

硅酸甲酯 98%

218472

硅酸甲酯

硅酸甲酯 purum, ≥98.0% (GC)

87682

硅酸甲酯

原硅酸四乙酯 reagent grade, 98%

131903

原硅酸四乙酯

assay

≥99%

assay

98%

assay

≥98.0% (GC)

assay

98%

mp

−4 °C (lit.)

mp

−4 °C (lit.)

mp

−4 °C (lit.)

mp

-

density

1.023 g/mL at 25 °C (lit.)

density

1.023 g/mL at 25 °C (lit.)

density

1.023 g/mL at 25 °C (lit.)

density

0.933 g/mL at 20 °C (lit.)

refractive index

n20/D 1.368 (lit.)

refractive index

n20/D 1.368 (lit.)

refractive index

n20/D 1.368 (lit.)

refractive index

n20/D 1.382 (lit.)

bp

121-122 °C (lit.)

bp

121-122 °C (lit.)

bp

121-122 °C (lit.)

bp

168 °C (lit.)

General description

Tetramethyl orthosilicate is a colorless organosilicon compound consisting of four methoxy groups bonded to a silicon atom. On hydrolysis, it produces silicon dioxide and methanol. It has been widely used in catalysis, synthesis of nanomaterials, ceramics, zeolites, and coating materials.[1][2]

Application

Tetramethyl orthosilicate can be used:
  • As a precursor to synthesize organic-inorganic coating materials by sol-gel processing method.[1]
  • As an efficient reagent for direct amidation of aliphatic and aromatic carboxylic acids with amines and anilines.[3]
  • As a precursor to fabricate SiO2 nanocomposite films by chemical vapor deposition(CVD) method.[2]
  • As a selective catalyst ofC3-methylation of indole.[4]
Used in the sol-gel synthesis of chromium-doped silicates and in the formation of hexagonal mesoporous silica layers.

Signal Word

Danger

Hazard Statements

H226,H315,H318,H330

Hazard Classifications

Acute Tox. 1 Inhalation - Eye Dam. 1 - Flam. Liq. 3 - Skin Irrit. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

78.8 °F - closed cup

Flash Point(C)

26 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    BCCL2070
    BCCH3075
    BCCH2464
    BCCH2086
    BCCG3627

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    Tetramethyl Orthosilicate (TMOS) as a Reagent for Direct Amidation of Carboxylic Acids
    D. Christopher Braddock, et al.
    Organic Letters, 20, 950-953 (2018)
    Tetramethyl orthosilicate as a sharp-selective catalyst of C3-methylation of indole by supercritical methanol
    I.V.Kozhevnikov, et al.
    Journal of Supercritical Fluids, 69, 82-90 (2012)
    Fabrication and characteristics of SiOx films by plasma chemical vapor deposition of tetramethylorthosilicate
    Mu-Rong Yang, et al.
    Surface and Coatings Technology, 123, 204-209 (2000)
    Preparation of sol-gel hybrid materials from gamma-methacryloxypropyltrimethoxysilane and tetramethyl orthosilicate: study of the hydrolysis and condensation reactions
    Amir A, et al.
    Colloid and Polymer Science, 289, 1875-1883 (2011)
    Zian Lin et al.
    Chemical communications (Cambridge, England), 47(34), 9675-9677 (2011-07-30)
    An inorganic-organic hybrid affinity monolithic column was synthesized by a novel "one-pot" approach. The resulting hybrid affinity monoliths have potential applications in specific recognition and enrichment of glycoproteins.
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