All Photos(2)
Synonym(s):
(+)-Methyl (R)-β-bromoisobutyrate
Linear Formula:
BrCH2CH(CH3)CO2CH3
CAS Number:
Molecular Weight:
181.03
Beilstein:
1720833
MDL number:
UNSPSC Code:
12352101
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
Assay
97%
form
liquid
optical activity
[α]20/D +16°, neat
optical purity
ee: 99% (GLC)
refractive index
n20/D 1.455 (lit.)
bp
85 °C/37 mmHg (lit.)
density
1.422 g/mL at 25 °C (lit.)
SMILES string
COC(=O)[C@@H](C)CBr
InChI
1S/C5H9BrO2/c1-4(3-6)5(7)8-2/h4H,3H2,1-2H3/t4-/m0/s1
InChI key
FKWNAVCXZSQYTA-BYPYZUCNSA-N
Application
Methyl (R)-(+)-3-bromo-2-methylpropionate can be used as a reactant to prepare:
It can also be used as a reference compound in the enantioselective alkylation reaction of hydrophobic vitamin B12 derivatives.
- (S)-3-(6-Methoxy-pyridin-3-yl)-2-methylpropionic acid methylester by reacting with 5-bromo-2-methoxy pyridine via nucleophilic displacement reaction.
- Decahydroisoquinoline derivative (NVP-ACQ090) as a potent antagonist of somatostatin sst3 receptor.
It can also be used as a reference compound in the enantioselective alkylation reaction of hydrophobic vitamin B12 derivatives.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
WGK
WGK 3
Flash Point(F)
163.4 °F
Flash Point(C)
73 °C
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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The development of a practical synthesis of the potent and selective somatostatin sst3 receptor antagonist [4-(3, 4-difluoro-phenyl)-piperazine-1-yl]-
Banziger M, et al.
Tetrahedron Asymmetry, 14(22), 3469-3477 (2003)
A 1H NMR and molecular modelling investigation of diastereotopic methylene hydrogen atoms.
Tormena CF, et al.
Magnetic Resonance in Chemistry, 40(4), 279-283 (2002)
Hydrophobic vitamin B12. Part 12. Preparation, characterization and enantioselective alkylation of strapped hydrophobic-vitamin B12
Murakami Y, et al.
J. Chem. Soc. Perkin Trans. II, 14(6), 1175-1183 (1995)
Hydrophobic vitamin B12. Part 12. Preparation, characterization and enantioselective alkylation of strapped hydrophobic-vitamin B12.
Murakami Y, et al.
J. Chem. Soc. Perkin Trans. II, 6, 1175-1183 (1995)
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