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301450

4-Bromomethyl-6,7-dimethoxycoumarin

Name: 4-Bromomethyl-6,7-dimethoxycoumarin
Brand: ALDRICH

96%

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₁BrO₄

CAS Number:

88404-25-5

Molecular Weight:

299.12

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24858188

MDL number:

MFCD00011570

Beilstein/REAXYS Number:

4750487

Assay:

96%

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Properties

Quality Level

100

assay

96%

mp

212-216 °C (lit.)

fluorescence

λ_ex 322; λ_em 395 (Reaction product with acetic acid), λ_ex 354 nm; λ_em 435 nm in methanol

functional group

bromo, ester

SMILES string

COc1cc2OC(=O)C=C(CBr)c2cc1OC

InChI

1S/C12H11BrO4/c1-15-10-4-8-7(6-13)3-12(14)17-9(8)5-11(10)16-2/h3-5H,6H2,1-2H3

InChI key

JGODLBJJCNQFII-UHFFFAOYSA-N

Description

Application

4-Bromomethyl-6,7-dimethoxycoumarin was used as fluorescent labeling reagent for the reversed-phase HPLC separation and detection of carboxylic acids. It was also used as derivatization reagent:

for quantitation of clofibric, bezafibric and fenofibric acids in liver by liquid chromatography
in determination of the concentration of tripeptide glutathione by matrix-assisted laser desorption ionization time-of-flight mass spectrometry
for determination of carboxylic acids in chromatographic detection

pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Characterization of the single Ca(2+)-binding site on the Ca(2+)-ATPase reconstituted with short- or long-chain phosphatidylcholines.

A P Starling et al.

The Biochemical journal, 304 ( Pt 2), 569-575 (1994-12-01)

On reconstitution of the Ca(2+)-ATPase of skeletal muscle sarcoplasmic reticulum into bilayers of dimyristoleoylphosphatidylcholine [di(C14:1)PC] or dinervonylphosphatidylcholine [di(C24:1)PC] the stoichiometry of Ca2+ binding changes from the usual two Ca2+ ions bound per ATPase molecule to one Ca2+ ion bound per

Labeling the (Ca(2+)-Mg2+)-ATPase of sarcoplasmic reticulum with 4-(bromomethyl)-6,7-dimethoxycoumarin: detection of conformational changes.

H I Stefanova et al.

Biochemistry, 31(26), 6023-6031 (1992-07-07)

The (Ca(2+)-Mg2+)-ATPase of sarcoplasmic reticulum was labeled with 4-(bromomethyl)-6,7-dimethoxycoumarin. It was shown that a single cysteine residue (Cys-344) was labeled on the ATPase, with a 25% reduction in steady-state ATPase activity and no reduction in the steady-state rate of hydrolysis

Journal of Chromatography A, 269, 81-81 (1983)

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Global Trade Item Number

SKU	GTIN
301450-1G	04061826665398