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Merck
CN

287059

L-Prolinamide

98%, for peptide synthesis

Synonym(s):

(2S)-2-Carbamoylpyrrolidine

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About This Item

Empirical Formula (Hill Notation):
C5H10N2O
CAS Number:
Molecular Weight:
114.15
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
231-397-0
MDL number:
Beilstein/REAXYS Number:
80807
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Product Name

L-Prolinamide, 98%

InChI key

VLJNHYLEOZPXFW-BYPYZUCNSA-N

InChI

1S/C5H10N2O/c6-5(8)4-2-1-3-7-4/h4,7H,1-3H2,(H2,6,8)/t4-/m0/s1

SMILES string

NC(=O)[C@@H]1CCCN1

assay

98%

optical activity

[α]20/D −106°, c = 1 in ethanol

reaction suitability

reaction type: solution phase peptide synthesis

mp

95-97 °C (lit.)

application(s)

peptide synthesis

Quality Level

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Denis R St Laurent et al.
Bioorganic & medicinal chemistry letters, 22(19), 6063-6066 (2012-09-11)
In a previous disclosure,(1) we reported the dimerization of an iminothiazolidinone to form 1, a contributor to the observed inhibition of HCV genotype 1b replicon activity. The dimer was isolated via bioassay-guided fractionation experiments and shown to be a potent
Tor E Kristensen et al.
Organic letters, 11(14), 2968-2971 (2009-06-16)
A completely non-chromatographic and highly large-scale adaptable synthesis of acrylic polymer beads containing proline and prolineamides has been developed. Novel monomeric proline (meth)acrylates are prepared from hydroxyproline in only one step. Free-radical copolymerization then gives solid-supported proline organocatalysts directly in
Hidenobu Komeda et al.
European journal of biochemistry, 271(8), 1465-1475 (2004-04-07)
An amidase acting on (R,S)-piperazine-2-tert-butylcarboxamide was purified from Pseudomonas azotoformans IAM 1603 and characterized. The enzyme acted S-stereoselectively on (R,S)-piperazine-2-tert-butylcarboxamide to yield (S)-piperazine-2-carboxylic acid. N-terminal and internal amino acid sequences of the enzyme were determined. The gene encoding the S-stereoselective
Carlos R Baiz et al.
Chemical reviews, 120(15), 7152-7218 (2020-07-01)
Vibrational spectroscopy is an essential tool in chemical analyses, biological assays, and studies of functional materials. Over the past decade, various coherent nonlinear vibrational spectroscopic techniques have been developed and enabled researchers to study time-correlations of the fluctuating frequencies that
Stamatis Fotaras et al.
Organic & biomolecular chemistry, 10(29), 5613-5619 (2012-06-22)
A tripeptide-like prolinamide-thiourea catalyst with (S)-proline, (1S,2S)-diphenylethylenediamine and (S)-di-tert-butyl aspartate as building blocks provides the products of the reaction between ketones and aromatic aldehydes in high to quantitative yields and high stereoselectivities (up to 99:1 dr and 99% ee). Both

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