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Assay
98%
SMILES string
[H][C@]1(OC(=O)c2c3OCOc3ccc12)[C@@]4([H])N(C)CCc5cc6OCOc6cc45
InChI
1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
InChI key
IYGYMKDQCDOMRE-ZWKOTPCHSA-N
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(+)-Bicuculline is a GABAA receptor antagonist.
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The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(19), 8276-8287 (2013-05-10)
Increasing evidence suggests that synchronization between brain regions is essential for information exchange and memory processes. However, it remains incompletely known which synaptic mechanisms contribute to the process of synchronization. Here, we investigated whether NMDA receptor-mediated synaptic plasticity was an
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(2), 697-708 (2013-01-11)
Motor tics, a cardinal symptom of Tourette syndrome (TS), are hypothesized to arise from abnormalities within cerebro-basal ganglia circuits. Yet noninvasive neuroimaging of TS has previously identified robust activation in the cerebellum. To date, electrophysiological properties of cerebellar activation and
Brain : a journal of neurology, 132(Pt 9), 2336-2349 (2009-07-31)
DYT1 dystonia is a severe form of inherited dystonia, characterized by involuntary twisting movements and abnormal postures. It is linked to a deletion in the dyt1 gene, resulting in a mutated form of the protein torsinA. The penetrance for dystonia
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(11), 4834-4842 (2013-03-15)
Although alcoholism is a worldwide problem resulting in millions of deaths, only a small percentage of alcohol users become addicted. The specific neural substrates responsible for individual differences in vulnerability to alcohol addiction are not known. In this study, we
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(47), 18661-18671 (2013-11-22)
G-protein-coupled receptors (GPCRs) may form heteromeric complexes and cooperatively mediate cellular responses. Although heteromeric GPCR complexes are suggested to occur in many neurons, their contribution to neuronal function remains unclear. We address this question using two GPCRs expressed in cerebellar
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