283746
4-(Aminomethyl)benzoic acid
97%, for peptide synthesis
Synonym(s):
PAMBA
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About This Item
Linear Formula:
H2NCH2C6H4CO2H
CAS Number:
Molecular Weight:
151.16
NACRES:
NA.22
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352106
EC Number:
200-297-9
MDL number:
Beilstein/REAXYS Number:
1100606
Product Name
4-(Aminomethyl)benzoic acid, 97%
InChI key
QCTBMLYLENLHLA-UHFFFAOYSA-N
InChI
1S/C8H9NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h1-4H,5,9H2,(H,10,11)
SMILES string
NCc1ccc(cc1)C(O)=O
assay
97%
form
powder
reaction suitability
reaction type: solution phase peptide synthesis
mp
≥300 °C (lit.)
application(s)
peptide synthesis
Quality Level
Application
4-(Aminomethyl)benzoic acid (PAMBA) can be used in the synthesis of:
- Cobalt carboxy phosphonates.
- Apoptozole (Az), which has cellular potency to promote membrane trafficking of mutant cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel activity.
- Cyclopeptide composed of L-glutamic acid and 3-aminobenzoic acid that can be used as receptors for a variety of cations and anions.
- A bioactive peptide which has potent GPR54 (a G protein-coupled receptor) agonistic activity.
Other Notes
4-(Aminomethyl)benzoic acid is also an antihemorrhagic agent, which is used for the treatment of internal haemorrhage.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Carlos F R A C Lima et al.
The journal of physical chemistry. A, 111(42), 10598-10603 (2007-10-05)
The standard (p0 = 0.1 MPa) molar enthalpies of combustion of six aminomethylbenzoic acids were measured at T = 298.15 K by static bomb calorimetry. With these values, the standard molar enthalpies of formation in the crystalline state were obtained.
A small molecule that binds to an ATPase domain of Hsc70 promotes membrane trafficking of mutant cystic fibrosis transmembrane conductance regulator.
Cho H J, et al.
Journal of the American Chemical Society, 133(50), 20267-20276 (2011)
G A Chalyĭ et al.
Zhurnal mikrobiologii, epidemiologii, i immunobiologii, (1)(1), 62-65 (1993-01-01)
The influence of protease-inhibiting preparations on the development of humoral immune response in diseases involving the development of secondary immunodeficiency (experimentally induced acute pancreatitis and staphylococcal infection) has been studied. Five injections of contrycal and epsilon-aminocaproic acid (epsilon-ACA), starting from
M N Iakushenko et al.
Zhurnal mikrobiologii, epidemiologii, i immunobiologii, (1)(1), 77-79 (1998-04-09)
The examination of 49 newborn infants revealed that at the early neonatal period the character of the microbial colonization of the intestine depended on the kind of perinatal pathology: in lesions of the central nervous system and conjugation jaundice the
Sandra Osburn et al.
Rapid communications in mass spectrometry : RCM, 21(21), 3409-3419 (2007-09-29)
Formation of [bn+17+cat]+ is a prominent collision-induced dissociation (CID) pathway for Li+- and Na+-cationized peptides. Dissociation of protonated and Ag+-cationized peptides instead favors formation of the rival bn+/[bn-1+cat]+ species. In this study the influence of a 4-aminomethylbenzoic acid (4AMBz) residue
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