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Safety Information

281891

Sigma-Aldrich

1-Phenylpiperazine hydrochloride

99%

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About This Item

Empirical Formula (Hill Notation):
C10H14N2 · HCl
CAS Number:
Molecular Weight:
198.69
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:

Assay

99%

mp

247-250 °C (lit.)

SMILES string

Cl[H].C1CN(CCN1)c2ccccc2

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Tiantian Mou et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 67(11), 2013-2018 (2009-08-15)
This study reports the synthesis and characterization of N-(3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl-4-[(18)F]fluorobenzamide ([(18)F]MPP3F). The total reaction time for [(18)F]MPP3F, including final high-performance liquid chromatography purification, was about 3h. Typical decay-corrected radiochemical yield was 18.4+/-3.1%. The radiochemical purity was >98%. Biodistribution in mice showed
Gürkan Keşan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 88, 144-155 (2012-01-10)
New metal halide complexes in the form of M(pp)(2)Cl(2) (where pp=1-phenylpiperazine and M=Pd or Hg) have been prepared for the first time and their FT-IR and FT-Raman spectra are reported in the region of 4000-10 cm(-1) and 4000-50 cm(-1), respectively.
Daniela Huber et al.
Bioorganic & medicinal chemistry, 20(1), 455-466 (2011-11-22)
Merging two arylamidoalkyl substituted phenylpiperazines as prototypical recognition elements for dopamine D(2)-like receptors by oligoethylene glycol linkers led to a series of bivalent ligands. These dimers were investigated in comparison to their monomeric analogues for their dopamine D(2long), D(2short), D(3)
Rodolfo do Couto Maia et al.
Expert opinion on therapeutic patents, 22(10), 1169-1178 (2012-09-11)
The N-phenylpiperazine subunit represents one of the most versatile scaffolds used in the medicinal chemistry field. Recently, some N-phenylpiperazine derivatives have reached late stage clinical trials for the treatment of CNS disorders, thus, this is clearly a molecular template that
Daniela Poli et al.
Journal of medicinal chemistry, 54(7), 2102-2113 (2011-03-16)
Following a molecular simplification approach, we have identified the 2-phenylphthalazin-1(2H)-one (PHTZ) ring system as a new decorable core skeleton for the design of novel hA(3) adenosine receptor (AR) antagonists. Interest for this new series was driven by the structural similarity

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