279277
N-(Hydroxymethyl)nicotinamide
98%
Synonym(s):
3-Pyridinecarboxylic acid N-hydroxymethylamide
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About This Item
Empirical Formula (Hill Notation):
C7H8N2O2
CAS Number:
Molecular Weight:
152.15
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Assay
98%
mp
152-154 °C (lit.)
SMILES string
OCNC(=O)c1cccnc1
InChI
1S/C7H8N2O2/c10-5-9-7(11)6-2-1-3-8-4-6/h1-4,10H,5H2,(H,9,11)
InChI key
JRFKIOFLCXKVOT-UHFFFAOYSA-N
General description
A quantitative determination of N-(hydroxymethyl)nicotinamide in tablets and basic solutions along with nicotinic acid by thin-layer chromatography-densitometric method has been reported. N-(Hydroxymethyl)nicotinamide is an antimicrobial agent.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Urszula Hubicka et al.
Journal of AOAC International, 91(5), 1186-1190 (2008-11-05)
A thin-layer chromatography (TLC)-densitometric method was developed to determine N-(hydroxymethyl)nicotinamide in tablets and basic solutions along with nicotinic acid. Analysis was performed on silica gel F254 plates using chloroform-ethanol (2 + 3, v/v) mobile phase. The densitometric observations were made
H K Zhang et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 27(8), 629-631 (1992-01-01)
N-Hydroxymethyl-nicotinamide, an antimicrobic agent was prepared in good yield by treating nicotinamide with excess of formaldehyde in the presence of potassium carbonate. The condensation reaction was studied under different conditions, changing the amount of formaldehyde, with different kinds of bases
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