275581
6-Aminoquinoline
98%
Synonym(s):
6-Quinolinamine
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About This Item
Empirical Formula (Hill Notation):
C9H8N2
CAS Number:
Molecular Weight:
144.17
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
209-453-0
Beilstein/REAXYS Number:
113320
MDL number:
Assay:
98%
Form:
solid
form
solid
assay
98%
InChI key
RJSRSRITMWVIQT-UHFFFAOYSA-N
InChI
1S/C9H8N2/c10-8-3-4-9-7(6-8)2-1-5-11-9/h1-6H,10H2
SMILES string
Nc1ccc2ncccc2c1
bp
146 °C/0.3 mmHg (lit.)
Quality Level
mp
115-119 °C (lit.)
Related Categories
Application
6-Aminoquinoline was used as an internal standard in determining serum nicotine and cotinine simultaneously by using high-performance liquid chromatography (HPLC)-fluorometric detection with a postcolumn ultraviolet-photoirradiation system. It was also used as a fluorescent derivatizing agent for the detection of biochemicals and in the synthesis of tertiary N-methylated enaminonesa.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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6-aminoquinoline as a fluorogenic leaving group in peptide cleavage reactions: a new fluorogenic substrate for chymotrypsin.
P J Brynes et al.
Analytical biochemistry, 116(2), 408-413 (1981-09-15)
G Viola et al.
Toxicology in vitro : an international journal published in association with BIBRA, 18(5), 581-592 (2004-07-15)
Three selected aminoquinolones endowed with a potent antibacterial (compounds 1 and 2) and antiviral activity (compound 3) have been evaluated for their phototoxic properties in vitro. Photostability studies of these compounds indicate that compound 3 is photostable whereas compound 1
J H Yu et al.
Journal of chromatography. B, Biomedical applications, 658(2), 249-260 (1994-08-19)
A new polymeric reagent containing the 6-aminoquinoline (6-AQ) tag was developed and applied for the off-line derivatization of amines and amino acids in high-performance liquid chromatography (HPLC). The synthesis and characterization of this polymeric reagent are described. An authentic external
Bryan P Ruddy et al.
Journal of controlled release : official journal of the Controlled Release Society, 306, 83-88 (2019-06-01)
Subcutaneous delivery of nicotine was performed using a novel electrically-operated needle-free jet injector, and compared to hypodermic needle delivery in a porcine model. Nicotine was delivered as a single, one-milligram dose into the abdominal skin, formulated as a 50 microliter
Pierre-Jean Aragon et al.
Chemical & pharmaceutical bulletin, 52(6), 659-663 (2004-06-10)
Indoloquinoline alkaloid cryptolepine and pyridocarbazole alkaloid ellipticine are of great interest because in vitro and in vivo studies revealed their good cytotoxic properties. In order to obtain some biologically active analogs of these compounds, we developped a synthesis based on
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