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275514

Sigma-Aldrich

6-Aza-2-thiothymine

99%

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Synonym(s):
2-Thio-6-azathymine, 3,4-Dihydro-6-methyl-3-thioxo-1,2,4-triazin-5(2H)-one
Empirical Formula (Hill Notation):
C4H5N3OS
CAS Number:
Molecular Weight:
143.17
Beilstein:
4861
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:

Assay

99%

mp

218-221 °C (lit.)

solubility

formic acid: soluble 5%, clear, colorless to light yellow-green

SMILES string

CC1=NNC(=S)NC1=O

InChI

1S/C4H5N3OS/c1-2-3(8)5-4(9)7-6-2/h1H3,(H2,5,7,8,9)

InChI key

NKOPQOSBROLOFP-UHFFFAOYSA-N

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Application

6-Aza-2-thiothymine was used in the preparation of a matrix that was utilized for ionizing small molecules.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Alba Hykollari et al.
Electrophoresis, 38(17), 2175-2183 (2017-05-31)
The unusual nature of the N-glycans of the cellular slime mould Dictyostelium discoideum has been revealed by a number of studies, primarily based on examination of radiolabeled glycopeptides but more recently also by MS. The complexity of the N-glycomes of
Hao-Hua Deng et al.
Nanomaterials (Basel, Switzerland), 10(2) (2020-02-13)
This study puts forward an efficient method for protein detection in virtue of the tremendous fluorescence enhancement property of 6-aza-2-thio-thymine protected gold nanoclusters (ATT-AuNCs). In-depth studies of the protein-induced photoluminescence enhancement mechanism illustrate the mechanism of the interaction between ATT-AuNCs
David Weigt et al.
Scientific reports, 8(1), 11260-11260 (2018-07-28)
Recent advances in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry have enabled whole cell-MALDI mass spectrometry biotyping of drug-treated cultured cells for rapid monitoring of known abundant pharmacodynamic protein markers such as polyacetylated histones. In contrast, generic and automated analytical workflows
Thomas Clairfeuille et al.
Nature, 584(7821), 479-483 (2020-08-14)
Lipopolysaccharide (LPS) resides in the outer membrane of Gram-negative bacteria where it is responsible for barrier function1,2. LPS can cause death as a result of septic shock, and its lipid A core is the target of polymyxin antibiotics3,4. Despite the
Shi Yan et al.
Analytical chemistry, 90(1), 928-935 (2017-11-29)
Despite years of research, the glycome of the model nematode Caenorhabditis elegans is still not fully understood. Certainly, data over the years have indicated that this organism synthesizes unusual N-glycans with a range of galactose and fucose modifications on the

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