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255335

Sigma-Aldrich

2-Thiophenesulfonyl chloride

96%

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About This Item

Empirical Formula (Hill Notation):
C4H3ClO2S2
CAS Number:
Molecular Weight:
182.65
Beilstein:
123536
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Assay

96%

bp

130-132 °C/14 mmHg (lit.)

mp

30-32 °C (lit.)

SMILES string

ClS(=O)(=O)c1cccs1

InChI

1S/C4H3ClO2S2/c5-9(6,7)4-2-1-3-8-4/h1-3H

InChI key

VNNLHYZDXIBHKZ-UHFFFAOYSA-N

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General description

Kinetics of reactions of 2-thiophenesulfonyl chloride with substituted anilines in methanol has been reported. Kinetics of solvolysis of 2-thiophenesulfonyl chloride in binary solvent mixtures has been studied.

Application

2-Thiophenesulfonyl chloride has been used in the preparation of 2-((trans-2-phenyl cyclopropyl)sulfonyl)thiophene.

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Malcolm J D'Souza et al.
International journal of molecular sciences, 9(5), 914-925 (2009-03-28)
Specific rates of solvolysis in hydroxylic solvents available for the solvolysis of 2-thiophenesulfonyl chloride and phenylmethanesulfonyl chloride are supplemented by determining the values in fluoroalcohol-containing solvents. The data sets are then correlated using the extended Grunwald-Winstein equation. For both substrates
Reaction kinetics of 3-thiophenesulfonyl chloride with anilines in methanol.
Arcoria A, et al.
The Journal of Organic Chemistry, 39(12), 1689-1691 (1974)
2-(trans-. beta.-Styrylsulfonyl)-and 2-((trans-2-phenylcyclopropyl) sulfonyl) thiophene.
Goralski CT.
The Journal of Organic Chemistry, 37(14), 2354-2355 (1972)
Radoslaw Laufer et al.
Bioorganic & medicinal chemistry, 22(17), 4968-4997 (2014-07-22)
TTK kinase was identified by in-house siRNA screen and pursued as a tractable, novel target for cancer treatment. A screening campaign and systematic optimization, supported by computer modeling led to an indazole core with key sulfamoylphenyl and acetamido moieties at

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