254940
Methyl acetimidate hydrochloride
technical grade
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CH3C(=NH)OCH3 · HCl
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grade
technical grade
Quality Level
mp
105 °C (dec.) (lit.)
storage temp.
2-8°C
SMILES string
Cl.COC(C)=N
InChI
1S/C3H7NO.ClH/c1-3(4)5-2;/h4H,1-2H3;1H
InChI key
WHYJXXISOUGFLJ-UHFFFAOYSA-N
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General description
Methyl acetimidate hydrochloride is an inhibitor of N-methylation of phosphatidylethanolamine. It also prevents the stimulation of purified cardiac sarcolemmal vesicles Ca2+-pump activities.
Application
Methyl acetimidate hydrochloride has been used in pre-crystallization chemical modification of lysine residues.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Biochemical and biophysical research communications, 130(1), 472-478 (1985-07-16)
Incubation of cardiac sarcoplasmic reticulum (SR) in the presence of S-adenosyl-L-methionine, a methyl donor for the enzymatic N-methylation of phosphatidylethanolamine, increased Ca2+-stimulated ATPase activity. The increase in Ca2+-ATPase activity was not due to changes in the affinity for Ca2+ and
Mutation research, 180(1), 121-129 (1987-09-01)
The cytogenetic effects of methyl acetimidate (MAI), a lysine-specific protein crosslinking reagent, were investigated using human peripheral lymphocytes in culture. Lymphocytes were treated with the chemical either prior to PHA exposure or 2-3 days following mitogenic stimulation and assessed for
The Journal of biological chemistry, 256(11), 5324-5326 (1981-06-10)
The appearance of an immune response in some sickle cell anemia patients to reinfused autologous erythrocytes which had been treated with methyl acetimidate (Gabuzda, T. G., Chao, T. L., Berenfeld, M. R., and Gelbart, T. (1980) Blood 56, 1041--1047) was
Hemoglobin, 5(1), 47-72 (1981-01-01)
The contribution of the high molecular weight hemoglobin (HMW Hb) to the antisickling effect produced by treatment of sickle cell erythrocytes with methyl acetimidate (MAI) was investigated. Erythrocytes obtained from sickle cell anemia and normal individuals were incubated with varying
Activation/inactivation of human angiotensin I converting enzyme following chemical modifications of amino groups near the active site.
Biochemical and biophysical research communications, 104(4), 1319-1326 (1982-02-26)
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