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253421

Sigma-Aldrich

3-(2-Iodoacetamido)-PROXYL

free radical

Synonym(s):

3-(2-Iodoacetamido)-2,2,5,5-tetramethyl-1-pyrrolidinyloxy, free radical

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About This Item

Empirical Formula (Hill Notation):
C10H18IN2O2
CAS Number:
27048-01-7
Molecular Weight:
325.17
MDL number:
MFCD00010161
UNSPSC Code:
12352101
PubChem Substance ID:
24855311
NACRES:
NA.22

form

solid

mp

162-164 °C (lit.)

storage temp.

2-8°C

SMILES string

CC1(C)CC(NC(=O)CI)C(C)(C)N1[O]

InChI

1S/C10H18IN2O2/c1-9(2)5-7(12-8(14)6-11)10(3,4)13(9)15/h7H,5-6H2,1-4H3,(H,12,14)

InChI key

OQIGMSGDHDTSFA-UHFFFAOYSA-N

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General description

3-(2-Iodoacetamido)-PROXYL is a free radical used as a spin probe in spin labeling techniques. This technique is helpful in investigating the dynamic aspects of molecular interactions of substances, proteins, lipids, and cell membranes.

Application

Sulfhydryl group specific spin label. Applications include study of ozone-treated human and bovine erythrocyte membrane proteins and the orientation of myosin subfragment on muscle fibers. DNA fragments containing phosphorothioate diesters can be labeled by spin labels.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A combined method, employing NMR and EPR spectroscopies, has demonstrated its strength in solving structures of protein/RNA and other types of biomolecular complexes. This method works particularly well when the large biomolecular complex consists of a limited number of rigid
N E Conway et al.
Nucleic acids symposium series, (21)(21), 43-44 (1989-01-01)
DNA fragments containing phosphorothioate diesters provide nucleophilic sites which are amenable to labeling by spin labels or fluorophores. Selecting the position for an individual phosphorothioate diester allows highly specific placement of the reporter group. The substitution of a phosphorothioate diester
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Biochemistry, 43(19), 5842-5852 (2004-05-12)
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