Skip to Content
Merck
CN

251569

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone

98%, for peptide synthesis

Synonym(s):

1,3-Dimethyl-2-oxohexahydropyrimidine, N,N′-Dimethylpropylene urea, DMPU

Sign In to View Organizational & Contract Pricing

Select a Size

About This Item

Empirical Formula (Hill Notation):
C6H12N2O
CAS Number:
7226-23-5
Molecular Weight:
128.17
Beilstein:
110562
EC Number:
230-625-6
MDL number:
MFCD00006550
UNSPSC Code:
12352115
PubChem Substance ID:
24855140
NACRES:
NA.22

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone, 98%

Quality Level

200

Assay

98%

form

liquid

refractive index

n20/D 1.488 (lit.)

bp

146 °C/44 mmHg (lit.)

density

1.06 g/mL at 25 °C (lit.)

application(s)

peptide synthesis

SMILES string

CN1CCCN(C)C1=O

InChI

1S/C6H12N2O/c1-7-4-3-5-8(2)6(7)9/h3-5H2,1-2H3

InChI key

GUVUOGQBMYCBQP-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

Application

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone (DMPU) can be used:
  • As a versatile solvent in N-alkylation of amines
  • O-alkylation of aldoses , and in the synthesis of poly(aryl ethers).
  • As urea solvent in the synthesis of 1-aryl-3,4,5-substituted pyrazoles by cyclocondensation of arylhydrazine hydrochlorides with 1,3-diketones.
  • As an additive in asymmetric cyanoamidation.

DMPU/HF can be used as a nucleophilic fluorinating agent in fluoro-Prins reaction for the synthesis of substituted 4-fluorotetrahydropyrans and 4-fluoropiperidines.
Versatile solvent employed in N-alkylation of chiral, primary amines, O-alkylation of aldoses, and in the synthesis of poly(aryl ethers).

Signal Word

Danger

Hazard Statements

H302,H318,H361f

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

249.8 °F - closed cup

Flash Point(C)

121 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
STBK7068
STBK9202
STBK1946
STBK1947
STBJ8314

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Protecting Groups: Strategies and Applications in Carbohydrate Chemistry, 41(11), 337-370 (2019)
Liebigs Ann. Chem., 683-683 (1993)
Synthesis, 1243-1243 (1993)
Thianthrene as an activating group for the synthesis of poly (aryl ether thianthrene)s by nucleophilic aromatic substitution
Edson JB and Knauss DM
Journal of Polymer Science Part A: Polymer Chemistry, 42(24), 6353-6363 (2004)
Intermolecular N-alkylation of amines under conditions of the Mitsunobu reaction: a new solid-phase synthesis of tertiary benzylamines
Zaragoza, Florencio and Stephensen, Henrik
Tetrahedron Letters, 41(11), 1841-1844 (2000)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service