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Assay
98%
form
solid
mp
40-42 °C (lit.)
SMILES string
[O-][N+](=O)c1ccc(F)c(Cl)c1
InChI
1S/C6H3ClFNO2/c7-5-3-4(9(10)11)1-2-6(5)8/h1-3H
InChI key
DPHCXXYPSYMICK-UHFFFAOYSA-N
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General description
2-Chloro-1-fluoro-4-nitrobenzene undergoes reduction in the presence of Mo(CO)6 and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) under microwave irradiation to yield a mixture of 3-chloro-4-fluoroaniline and 3-chloro-4-ethoxyaniline.
Application
2-Chloro-1-fluoro-4-nitrobenzene has been used in synthesis of:
- benzoimidolones on Ameba resin
- methyl 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-ylacetate
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
WGK
WGK 3
Flash Point(F)
235.4 °F
Flash Point(C)
113 °C
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Microwave mediated reduction of heterocycle and fluorine containing nitroaromatics with Mo (CO)6 and DBU.
Tetrahedron, 64(44), 10195-10200 (2008)
Practical and efficient synthesis of N-fused tricyclic indoles.
Tetrahedron Letters, 52(1), 122-124 (2011)
Microwave-assisted traceless synthesis of benzimidazolones.
Tetrahedron Letters, 48(1), 129-132 (2007)
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