Skip to Content
Merck
CN
All Photos(2)

Documents

233226

Sigma-Aldrich

2,4-Difluoronitrobenzene

99%

Sign Into View Organizational & Contract Pricing
All Photos(2)
Synonym(s):
2,4-Difluoro-1-nitrobenzene
Linear Formula:
F2C6H3NO2
CAS Number:
446-35-5
Molecular Weight:
159.09
EC Number:
207-167-0
MDL number:
MFCD00007050
UNSPSC Code:
12352100
PubChem Substance ID:
24853961
NACRES:
NA.22

vapor density

>1 (vs air)

Quality Level

100

Assay

99%

form

liquid

refractive index

n20/D 1.511 (lit.)

bp

203-204 °C (lit.)

mp

9-10 °C (lit.)

density

1.451 g/mL at 25 °C (lit.)

SMILES string

[O-][N+](=O)c1ccc(F)cc1F

InChI

1S/C6H3F2NO2/c7-4-1-2-6(9(10)11)5(8)3-4/h1-3H

InChI key

RJXOVESYJFXCGI-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine has been investigated using flow reactor with simulated moving bed (SMB) chromatography module.

Application

2,4-Difluoronitrobenzene has been used in the synthesis of:
  • 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction
  • (±)-horsfiline
  • resin-bound 2-arylaminobenzimidazoles

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301,H315,H319,H335

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

closed cup

Flash Point(C)

closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

U M Kremer
Biological chemistry Hoppe-Seyler, 371(9), 861-864 (1990-09-01)
2,4-Difluoro-5-nitrobenzenesulfonic acid has been synthesized by the sulfonation of 2,4-difluoronitrobenzene, and precipitated with KCl as the potassium sulfonate. The structure was confirmed by chemical and spectroscopic methods (IR, 1H-NMR, 13C-NMR, 19F-NMR, UV, MS and ultimate organic analysis). Lysozyme was cross-linked
Alexander G O'Brien et al.
Angewandte Chemie (International ed. in English), 51(28), 7028-7030 (2012-06-08)
Continuous synthesis meets continuous purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine the desired monosubstituted product can be continuously separated from the byproducts in a purity of over 99 %
A solid phase traceless synthesis of 2-arylaminobenzimidazoles.
Krchnak V, et al.
Tetrahedron Letters, 42(9), 1627-1630 (2001)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service