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Merck
CN

226017

1,2-Naphthoquinone-4-sulfonic acid sodium salt

97%

Synonym(s):

3,4-Dihydro-3,4-dioxo-1-naphthalenesulfonic acid sodium salt, Folin’s reagent, Sodium 1,2-naphthoquinone-4-sulfonate

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About This Item

Empirical Formula (Hill Notation):
C10H5NaO5S
CAS Number:
521-24-4
Molecular Weight:
260.20
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24853538
EC Number:
208-308-9
Beilstein/REAXYS Number:
4169788
MDL number:
MFCD00001700
Assay:
97%
Form:
powder

Key Documents

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InChI key

UBLXEEBHYISRFM-UHFFFAOYSA-M

InChI

1S/C10H6O5S.Na/c11-8-5-9(16(13,14)15)6-3-1-2-4-7(6)10(8)12;/h1-5H,(H,13,14,15);/q;+1/p-1

SMILES string

[Na+].[O-]S(=O)(=O)C1=CC(=O)C(=O)c2ccccc12

assay

97%

form

powder

mp

289 °C (dec.) (lit.)

solubility

alcohol: slightly soluble 95%, acetone: moderately soluble(lit.), benzene: insoluble(lit.), carbon disulfide: insoluble(lit.), chloroform: insoluble(lit.), diethyl ether: insoluble(lit.), petroleum ether: insoluble(lit.), water: soluble(lit.)

functional group

ketone, sulfonic acid

Quality Level

100

Related Categories

Application

1,2-Naphthoquinone-4-sulfonic acid sodium salt (Folin′s reagent) was used in the colorimetric assay for determination of procaine hydrochloride in pharmaceutical preparations.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN8457
BCCN7823
BCCM7597
BCCM7443
BCCM7598

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R B Salama et al.
Journal of pharmaceutical sciences, 69(3), 346-348 (1980-03-01)
A new rapid, specific, and convenient colorimetric method for the determination of procaine hydrochloride in pharmaceutical preparations is described. This method is based on measurement of the intensity of the orange-red color developed when procaine hydrochloride is allowed to react
R M Latorre et al.
Journal of chromatography. A, 934(1-2), 105-112 (2002-01-05)
This paper examines the potentiality of in-capillary derivatization for improving the sensitivity of the spectrophotometric detection of amino acids in capillary zone electrophoresis. 1,2-Naphthoquinone-4-sulfonate was selected as the labeling agent of amino acids. The underivatized sample and the reagent solution
Y Moliner-Martínez et al.
Journal of chromatography. A, 1059(1-2), 17-24 (2005-01-05)
A new method for dimethylamine determination in air is reported. The proposed assay is based on the employment of C18-packed solid phase extraction cartridges for sampling. The retained amine is then derivatized inside the cartridges with the reagent 1,2-naphthoquinone-4-sulfonate. By
Li Xiao Xu et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 59(13), 3103-3110 (2003-10-30)
Spectrophotometric determination of procaine hydrochloride is described. The procaine hydrochloride reacts with 1,2-naphthoquinone-4-sulfonic acid in pH 3.60 buffer solution to form a salmon pink compound, and its maximum absorption wavelength is at 484 nm, epsilon(484)=5.22 x 10(3).The absorbance for procaine
Masoumeh Hasani et al.
Analytical biochemistry, 365(1), 74-81 (2007-03-22)
A spectrophotometric method for simultaneous analysis of glycine and lysine is proposed by application of neural networks on the spectral kinetic data. The method is based on the reaction of glycine and lysine with 1,2-naphthoquinone-4-sulfonate (NQS) in slightly basic medium.
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