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Merck
CN

226017

1,2-Naphthoquinone-4-sulfonic acid sodium salt

97%

Synonym(s):

3,4-Dihydro-3,4-dioxo-1-naphthalenesulfonic acid sodium salt, Folin’s reagent, Sodium 1,2-naphthoquinone-4-sulfonate

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About This Item

Empirical Formula (Hill Notation):
C10H5NaO5S
CAS Number:
521-24-4
Molecular Weight:
260.20
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24853538
EC Number:
208-308-9
Beilstein/REAXYS Number:
4169788
MDL number:
MFCD00001700
Assay:
97%
Form:
powder

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InChI key

UBLXEEBHYISRFM-UHFFFAOYSA-M

InChI

1S/C10H6O5S.Na/c11-8-5-9(16(13,14)15)6-3-1-2-4-7(6)10(8)12;/h1-5H,(H,13,14,15);/q;+1/p-1

SMILES string

[Na+].[O-]S(=O)(=O)C1=CC(=O)C(=O)c2ccccc12

assay

97%

form

powder

mp

289 °C (dec.) (lit.)

solubility

alcohol: slightly soluble 95%, acetone: moderately soluble(lit.), benzene: insoluble(lit.), carbon disulfide: insoluble(lit.), chloroform: insoluble(lit.), diethyl ether: insoluble(lit.), petroleum ether: insoluble(lit.), water: soluble(lit.)

functional group

ketone, sulfonic acid

Quality Level

100

Related Categories

Application

1,2-Naphthoquinone-4-sulfonic acid sodium salt (Folin′s reagent) was used in the colorimetric assay for determination of procaine hydrochloride in pharmaceutical preparations.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN8457
BCCN7823
BCCM7597
BCCM7443
BCCM7598

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R B Salama et al.
Journal of pharmaceutical sciences, 69(3), 346-348 (1980-03-01)
A new rapid, specific, and convenient colorimetric method for the determination of procaine hydrochloride in pharmaceutical preparations is described. This method is based on measurement of the intensity of the orange-red color developed when procaine hydrochloride is allowed to react
D Hernando et al.
Journal of chromatography. A, 859(2), 227-233 (1999-11-26)
A liquid chromatographic method for the determination of aniline in cyclamate sweeteners based on a pre-column derivatization with 1,2-naphthoquinone-4-sulfonate (NQS) is proposed. Aniline traces were extracted from the cyclamate samples using dichloromethane. After solvent evaporation, the dry residue was derivatized
R M Latorre et al.
Journal of chromatography. A, 934(1-2), 105-112 (2002-01-05)
This paper examines the potentiality of in-capillary derivatization for improving the sensitivity of the spectrophotometric detection of amino acids in capillary zone electrophoresis. 1,2-Naphthoquinone-4-sulfonate was selected as the labeling agent of amino acids. The underivatized sample and the reagent solution
Y Moliner-Martínez et al.
Journal of chromatography. A, 1059(1-2), 17-24 (2005-01-05)
A new method for dimethylamine determination in air is reported. The proposed assay is based on the employment of C18-packed solid phase extraction cartridges for sampling. The retained amine is then derivatized inside the cartridges with the reagent 1,2-naphthoquinone-4-sulfonate. By
R M Latorre et al.
Electrophoresis, 21(3), 563-572 (2000-03-22)
The application of chemometric techniques to the resolution of overlapped peaks in capillary electrophoresis (CE) is described. When a physical separation can not be completely accomplished, chemometrics might still resolve the determination of the analytes mathematically. CE with diode array
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