224235
N,N′-Hexamethylene bis(acetamide)
98%
Synonym(s):
N,N′-Diacetyl-1,6-hexanediamine, HMBA
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About This Item
Linear Formula:
CH3CONH(CH2)6NHCOCH3
CAS Number:
Molecular Weight:
200.28
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Product Name
N,N′-Hexamethylene bis(acetamide), 98%
InChI
1S/C10H20N2O2/c1-9(13)11-7-5-3-4-6-8-12-10(2)14/h3-8H2,1-2H3,(H,11,13)(H,12,14)
SMILES string
CC(=O)NCCCCCCNC(C)=O
InChI key
BNQSTAOJRULKNX-UHFFFAOYSA-N
assay
98%
mp
128-129 °C (lit.)
solubility
water: soluble 5%, clear, colorless
functional group
amide
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Application
N,N′-Hexamethylene bis(acetamide) was used as an inducing agent in obtaining mononuclear cells from the peripheral blood (PB) sample by Ficoll-Hypaque gradient separation.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Maria Chatzopoulou et al.
European journal of medicinal chemistry, 50, 75-80 (2012-02-22)
Based on previous studies on bis-acetamides that act as hybrid polar compounds to induce leukemia cell differentiation, an attempt was made to bioisosterically replace the amide moiety with the lipophilic non-classical bioisostere tetrazole. A pyrrole group was also included in
Xuguang Zhu et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 23(2), 430-440 (2016-07-22)
New therapeutic approaches are needed for patients with thyroid cancer refractory to radioiodine treatment. An inhibitor of bromodomain and extraterminal domain (BET) proteins, JQ1, shows potent antitumor effects in hematological cancers and solid tumors. To evaluate whether JQ1 is effective
Wali Hafezi et al.
PLoS pathogens, 8(5), e1002679-e1002679 (2012-05-17)
Following productive, lytic infection in epithelia, herpes simplex virus type 1 (HSV-1) establishes a lifelong latent infection in sensory neurons that is interrupted by episodes of reactivation. In order to better understand what triggers this lytic/latent decision in neurons, we
Shailesh K Choudhary et al.
The Journal of infectious diseases, 197(8), 1162-1170 (2008-04-19)
Novel therapeutic approaches are needed to attack persistent proviral human immunodeficiency type 1 (HIV-1) infection. Hexamethylbisacetamide (HMBA), a hybrid bipolar compound, induces expression of the HIV-1 promoter in the long terminal repeat (LTR) region in a Tat-independent manner but mimics
Kara G Lassen et al.
PloS one, 7(1), e30176-e30176 (2012-02-01)
Latently infected cells form the major obstacle to HIV eradication. Studies of HIV latency have been generally hindered by the lack of a robust and rapidly deployable cell model that involves primary human CD4 T lymphocytes. Latently infected cell lines
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