208949
2-Fluorophenylacetic acid
98%
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About This Item
Linear Formula:
FC6H4CH2CO2H
CAS Number:
Molecular Weight:
154.14
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
207-196-9
Beilstein/REAXYS Number:
775955
MDL number:
Assay:
98%
Form:
solid
InChI key
RPTRFSADOICSSK-UHFFFAOYSA-N
InChI
1S/C8H7FO2/c9-7-4-2-1-3-6(7)5-8(10)11/h1-4H,5H2,(H,10,11)
SMILES string
OC(=O)Cc1ccccc1F
assay
98%
form
solid
mp
60-62 °C (lit.)
functional group
carboxylic acid, fluoro
General description
2-Fluorophenylacetic acid is chiral derivatizing agent for determination of enantiomeric composition of chiral, nonracemic compounds by 19F NMR spectroscopy.
Application
2-Fluorophenylacetic acid was used:
- in the synthesis of thiazolino[3,2-c]pyrimidin-5,7-diones and N-[2-(3,4-dichlorophenyl)-ethyl]-N′-[2-(2-fluorophenyl)-ethyl]-ethane-1,2-diamine
- as chiral derivatizing agent for determination of enantiomeric composition of chiral, nonracemic compounds by 19F NMR spectroscopy
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Joseph Pontillo et al.
Bioorganic & medicinal chemistry letters, 15(5), 1407-1411 (2005-02-17)
Treatment of various 2-methyl oxazolines or thiazolines with chlorocarbonyl isocyanate gives the corresponding bicyclic oxazolino- or thiazolino[3,2-c]pyrimidin-5,7-dione derivatives in very good yield. This reaction has been applied to the rapid syntheses of human gonadotropin-releasing hormone (hGnRH) receptor antagonists for SAR
Boron trifluoride-induced reactions of phenylglycidyl ethers: a convenient synthesis of enantiopure, stereodefined fluorohydrins.
Islas-Gonzalez G, et al.
Tetrahedron Letters, 45(33), 6337-6341 (2004)
Yaqun Li et al.
The Korean journal of pain, 34(1), 27-34 (2021-01-01)
Chemotherapy-induced peripheral neuropathy (CIPN) is a major reason for stopping or changing anticancer therapy. Among the proposed pathomechanisms underlying CIPN, proinflammatory processes have attracted increasing attention. Here we assessed the role of prostaglandin D2 (PGD2) signaling in cisplatin-induced neuropathic pain.
Jonathan M Fitzsimmons et al.
Medicinal chemistry, 1(102) (2011-12-25)
Eight halogenated
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