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Merck
CN

193232

1,4-Benzodioxan-6-amine

≥98%

Synonym(s):

6-Amino-1,4-benzodioxan

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About This Item

Empirical Formula (Hill Notation):
C8H9NO2
CAS Number:
22013-33-8
Molecular Weight:
151.16
NACRES:
NA.22
PubChem Substance ID:
24851588
UNSPSC Code:
12352100
EC Number:
244-718-4
MDL number:
MFCD00006824

Key Documents

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Product Name

1,4-Benzodioxan-6-amine, ≥98%

InChI key

BZKOZYWGZKRTIB-UHFFFAOYSA-N

InChI

1S/C8H9NO2/c9-6-1-2-7-8(5-6)11-4-3-10-7/h1-2,5H,3-4,9H2

SMILES string

Nc1ccc2OCCOc2c1

assay

≥98%

refractive index

n20/D 1.599 (lit.)

mp

29-31 °C (lit.)

density

1.231 g/mL (lit.)

Quality Level

100

Related Categories

Application

1,4-Benzodioxan-6-amine was used in the synthesis of N-(2-hydroxy-ethyl)-2,3-didehydroazapodophyllotoxins having anti-tumor activity and dioxanoacridinones.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
STBK2324
STBJ0538
STBG6078V
STBC7655V
STBC7654V

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2, 3-Dihydrodioxin [2, 3-b] acridin-11 (6H)-one.
Karolak-Wojciechowska J, et al.
Acta Crystallographica Section C, Crystal Structure Communications, 54(11), 1689-1690 (1998)
Ajay Kumar et al.
Journal of heterocyclic chemistry, 47(6), 1275-1282 (2011-01-05)
Novel arylamino alcohols were synthesized and these alcohols were used to prepare 12 novel N-(2-hydroxy-ethyl)-2,3-didehydroazapodophyllotoxins, in one step, by simple reflux in ethanol. Isolated yields in the range of 50-70% were obtained.
Elizabeth A Grossman et al.
Cell chemical biology, 24(11), 1368-1376 (2017-09-19)
Many natural products that show therapeutic activities are often difficult to synthesize or isolate and have unknown targets, hindering their development as drugs. Identifying druggable hotspots targeted by covalently acting anti-cancer natural products can enable pharmacological interrogation of these sites

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