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Merck
CN

191892

Hydroxypropyl cellulose

average Mw ~370,000, powder, 20 mesh particle size (99% through)

Synonym(s):

HPC

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About This Item

CAS Number:
9004-64-2
UNSPSC Code:
12162002
NACRES:
NA.23
MDL number:
MFCD00132688

Key Documents

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Product Name

Hydroxypropyl cellulose, average Mw ~370,000, powder, 20 mesh particle size (99% through)

SMILES string

N(C)(C)c1cc(c(cc1)C(N)CC)C

InChI

1S/C12H20N2/c1-5-12(13)11-7-6-10(14(3)4)8-9(11)2/h6-8,12H,5,13H2,1-4H3

InChI key

RRHXDYJWVYFMKV-UHFFFAOYSA-N

description

biological oxygen demand (BOD) 14,000 ppm

form

powder

autoignition temp.

752 °F

mol wt

average Mw ~370,000

impurities

<5 wt. %

particle size

20 mesh (99% through)

pH

5.0-8.5

interfacial tension mineral oil

12.5 dyn/cm, 0.1 wt. % in H2O (vs. mineral oil)

viscosity

150-400 cP, 2 wt. % in H2O(25 °C, Brookfield, spindle #2) (60 rpm)(lit.)

solubility

H2O: insoluble (above 45 °C)
polar organic solvents: soluble

density

0.5 g/mL at 25 °C (lit.)

Quality Level

100

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Application

Hydroxypropyl cellulose can be used to prepare composite nanospheres for drug delivery systems. Hydroxypropyl methacrylate/hydroxy cellulose graft copolymers can be used as matrices for controlled-release tablets. It can also be used as an electrolyte additive to prepare gel polymerelectrolytes for dye-sensitized solar cells.

General description

Hydroxypropyl cellulose (HPC) is a nonionic derivativeof cellulose. It is a thermosensitive, biodegradable polymer with low criticalsolution temperature.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX9965
MKCV5888
MKCQ9712
MKCS6391
MKCN1901

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Alexandre Monteiro et al.
Drug development and industrial pharmacy, 39(2), 266-283 (2012-04-17)
Nanoparticles of BCS Class II drugs are produced in wet stirred media mills operating in batch or recirculation mode with the goal of resolving the poor water-solubility issue. Scant information is available regarding the continuous production of drug nanoparticles via
Jianjun Yang et al.
International orthopaedics, 37(3), 515-521 (2012-11-28)
The aim of this study was to determine whether hydroxypropylcellulose (HPC) coating of polyethylene terephthalate (PET) artificial ligaments enhances graft osseointegration in the bone tunnel. Thirty New Zealand white rabbits underwent artificial ligament graft transplantation in the bilateral proximal tibia
Satomi Onoue et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 46(5), 492-499 (2012-04-14)
The present study was undertaken to develop a solid self-emulsifying drug delivery system of coenzyme Q(10) (CoQ(10)/s-SEDDS) with high photostability and oral bioavailability. The CoQ(10)/s-SEDDS was prepared by spray-drying an emulsion preconcentrate containing CoQ(10), medium-chain triglyceride, sucrose ester of fatty
Weibin Deng et al.
Drug development and industrial pharmacy, 39(2), 290-298 (2012-04-25)
The objective of this study was to improve the dissolution rate and to enhance the stability of a poorly water-soluble and low glass-trasition temperature (T(g)) model drug, fenofibrate, in low molecular weight grades of hydroxypropylcellulose matrices produced by hot-melt extrusion
Hyemin Choi et al.
Journal of pharmaceutical sciences, 101(8), 2941-2951 (2012-05-26)
Living organisms secrete minerals composed of peptides and proteins, resulting in "mesocrystals" of three-dimensional-assembled composite structures. Recently, this biomimetic polymer-directed crystallization technique has been widely applied to inorganic materials, although it has seldom been used with drugs. In this study
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