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Sigma-Aldrich

Dimethyl suberimidate dihydrochloride

98%

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Synonym(s):
DMS, Dimethyl ester octanediimidic acid dihydrochloride
Linear Formula:
CH3OC(=NH)CH2(CH2)4CH2C(=NH)OCH3 · 2HCl
CAS Number:
34490-86-3
Molecular Weight:
273.20
EC Number:
252-060-4
MDL number:
MFCD00012574
UNSPSC Code:
12352100
PubChem Substance ID:
24850817
NACRES:
NA.22

Quality Level

200

Assay

98%

form

powder

mp

213-214 °C (lit.)

SMILES string

Cl.COC(=N)CCCCCCC(=N)OC

InChI

1S/C10H20N2O2.2ClH/c1-13-9(11)7-5-3-4-6-8-10(12)14-2;;/h11-12H,3-8H2,1-2H3;2*1H

InChI key

ILKCDNKCNSNFMP-UHFFFAOYSA-N

Gene Information

rat ... Maoa(29253) , Maob(25750)

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General description

Dimethyl suberimidate dihydrochloride acts as a cross-linking agent for amino groups. It is used in the treatment of avian myeloblastosis virus (AMV).

Application

Reactant involved in:
  • Chemical modification of tyrosinase for coupling to produce biocatalytic enzymatic flow-through detectors
  • Cross-linker for synthesis of collagen-calcium phosphate composites

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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G Russ et al.
Acta virologica, 20(4), 336-338 (1976-08-01)
Treatment of intact avian myeloblastosis virus (AMV) with dimethyl suberimidate dihydrochloride (DMS), a cross-linking agent specific for amino groups, was found to result in progressive cross-linking among viral proteins, as revealed by polyacrylamide gel electrophoresis (PAGE) in the presence of

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