178330
4-Amino-1-butanol
98%
Synonym(s):
4-Hydroxybutylamine
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About This Item
Linear Formula:
H2N(CH2)4OH
CAS Number:
Molecular Weight:
89.14
Beilstein:
1731411
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Quality Level
Assay
98%
form
liquid
refractive index
n20/D ~1.462 (lit.)
bp
206 °C (lit.)
mp
16-18 °C (lit.)
density
0.967 g/mL at 25 °C (lit.)
SMILES string
NCCCCO
InChI
1S/C4H11NO/c5-3-1-2-4-6/h6H,1-5H2
InChI key
BLFRQYKZFKYQLO-UHFFFAOYSA-N
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Application
4-Amino-1-butanol was used in the synthesis of cyclic amines.
4-Amino-1-butanol was used:
- As a linker in the synthesis of highly branched poly(β-amino esters)(HPAEs) for gene delivery.
- As a side chain to modulate antimicrobial and hemolytic activities of copolymers.
- In the total synthesis of (+)-fawcettimine,(+)-fawcettidine, and (−)-lycojapodine A.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
WGK
WGK 2
Flash Point(F)
closed cup
Flash Point(C)
closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Highly branched poly (β-amino esters): Synthesis and application in gene delivery.
Cutlar L, et al.
Biomacromolecules, 16(9), 2609-2617 (2015)
Christopher L Grigsby et al.
Scientific reports, 3, 3155-3155 (2013-11-07)
As the designs of polymer systems used to deliver nucleic acids continue to evolve, it is becoming increasingly apparent that the basic bulk manufacturing techniques of the past will be insufficient to produce polymer-nucleic acid nanocomplexes that possess the uniformity
Synthesis of cyclic amines and their alkyl derivatives from amino alcohols over supported copper catalysts.
Applied Catalysis, 53(1), 107-115 (1989)
Cationic spacer arm design strategy for control of antimicrobial activity and conformation of amphiphilic methacrylate random copolymers.
Palermo E F, et al.
Biomacromolecules, 13(5), 1632-1641 (2012)
Total Syntheses of Lycopodium Alkaloids (+)?Fawcettimine,(+)?Fawcettidine, and (−)?8?Deoxyserratinine.
Li H, et al.
Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 124(2), 506-510 (2012)
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