169102
1-Docosanol
98%
Synonym(s):
Behenyl alcohol
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About This Item
Linear Formula:
CH3(CH2)21OH
CAS Number:
Molecular Weight:
326.60
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
211-546-6
Beilstein/REAXYS Number:
1770470
MDL number:
Assay:
98%
InChI key
NOPFSRXAKWQILS-UHFFFAOYSA-N
InChI
1S/C22H46O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23/h23H,2-22H2,1H3
SMILES string
CCCCCCCCCCCCCCCCCCCCCCO
assay
98%
bp
180 °C/0.22 mmHg (lit.)
mp
65-72 °C (lit.)
functional group
hydroxyl
Quality Level
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General description
1-Docosanol inhibits replication of certain viruses (herpes simplex virus and respiratory syncytial virus) within primary target cells in vitro. It has been isolated from Clematis brevicaudata.
Application
1-Docosanol was used in the synthesis of series of amphiphilic dendrimers with hydrophilic aliphatic polyether-type dendritic core and hydrophobic docosyl peripheries.
Storage Class
11 - Combustible Solids
wgk
nwg
flash_point_f
410.0 °F
flash_point_c
210 °C
ppe
Eyeshields, Gloves, type N95 (US)
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Ai-Mei Yang et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 32(10), 1534-1537 (2010-02-02)
To study the chemical constituents from Clematis brevicaudata. The compounds were isolated by column chromatography and their structures were elucidated through spectroscopic analysis (NMR). Eight compounds were isolated and identified as: palmitic acid (1), 1-docosanol (2), pentacosanoic acid-2', 3'-dihydroxypropyl ester
Antiviral activity of 1-docosanol, an inhibitor of lipid-enveloped viruses including herpes simplex.
D H Katz et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(23), 10825-10829 (1991-12-01)
This article reports that 1-docosanol, a 22-carbon-long saturated alcohol, exerts a substantial inhibitory effect on replication of certain viruses (e.g., herpes simplex virus and respiratory syncytial virus) within primary target cells in vitro. To study the basis for its viral
Kei Watanabe et al.
Journal of oleo science, 61(1), 29-34 (2011-12-23)
In this study, the changes in the structural and physicochemical properties of an α-crystalline phase (often called an "α-gel") were assessed in a sodium methyl stearoyl taurate (SMT)/behenyl alcohol/water system. The α-gels were characterized focusing on the effects of the
Jean Pierre Raynaud et al.
The Journal of steroid biochemistry and molecular biology, 82(2-3), 233-239 (2002-12-13)
In different cell systems, the lipido-sterolic extract of Serenoa repens (LSESr, Permixon inhibits both type 1 and type 2 5alpha-reductase activity (5alphaR1 and 5alphaR2). LSESr is mainly constituted of fatty acids (90+/-5%) essentially as free fatty acids (80%). Among these
A review of antiviral therapy for herpes labialis.
M Vander Straten et al.
Archives of dermatology, 137(9), 1232-1235 (2001-09-18)
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