All Photos(3)
Synonym(s):
4,6-Dihydroxy-1,3,5-triazine-2-carboxylic acid potassium salt, Allantoxanic acid
Empirical Formula (Hill Notation):
C4H2KN3O4
CAS Number:
Molecular Weight:
195.17
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
Quality Level
Assay
97%
mp
300 °C (lit.)
SMILES string
[K+].[O-]C(=O)C1=NC(=O)NC(=O)N1
InChI
1S/C4H3N3O4.K/c8-2(9)1-5-3(10)7-4(11)6-1;/h(H,8,9)(H2,5,6,7,10,11);/q;+1/p-1
InChI key
IAPCTXZQXAVYNG-UHFFFAOYSA-M
Related Categories
Application
Oxonic acid potassium salt is an inhibitor of uricase. The product from Sigma has been used for the inhibition of 5-fluorouracil-induced gastrointestinal toxicity without the loss of its antitumor activity in rats. It has also been used to induce hyperuricemia in rats; as it inhibits uric acid metabolism.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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T Shirasaka et al.
Cancer research, 53(17), 4004-4009 (1993-09-01)
The possibility of decreasing the gastrointestinal (GI) toxic effects of 5-fluorouracil (5-FU) on the digestive tract such as its injury of cells and induction of diarrhea, without reducing its antitumor activity, was investigated in rats. Oxonic acid was found to
Jieyu Zuo et al.
The Journal of pharmacy and pharmacology, 70(1), 124-132 (2017-10-24)
Traditional Chinese herbal formulas are difficult to be understood because of complex compositions and specific therapeutic principles. To better understand herbal compatibility in Traditional Chinese medicine (TCM), this study was conducted to investigate the effects of a Chinese pharmacopoeia-listed formula
Haruka Fujikawa et al.
Antioxidants (Basel, Switzerland), 9(5) (2020-05-10)
The oxidant/antioxidant imbalance plays a pivotal role in the lung. Uric acid (UA), an endogenous antioxidant, is highly present in lung tissue, however, its impact on lung function under pathophysiological conditions remains unknown. In this work, pharmacological and genetic inhibition
Kei Nishizawa et al.
PloS one, 14(4), e0214862-e0214862 (2019-04-06)
The effects of hyperuricemia on the expression of kidney drug transporters and on the pharmacokinetics of several substrate drugs were examined. We first established a rat model of hyperuricemia without marked symptoms of chronic kidney failure by 10-day co-administration of
Ning Liu et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(10), 13474-13493 (2020-08-12)
Potential underlying molecular mechanisms for uric acid-induced lipid metabolic disturbances had not been elucidated clearly. This study investigated the effects and underlying mechanisms of uric acid on the development of lipid metabolic disorders. We collected blood samples from 100 healthy
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