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Merck
CN

15225

Bistrifluoroacetamide

Synonym(s):

BTFA

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About This Item

Linear Formula:
(CF3CO)2NH
CAS Number:
Molecular Weight:
209.05
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
206-981-3
Beilstein/REAXYS Number:
1793118
MDL number:
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InChI key

GMQVFHZSXKJCIV-UHFFFAOYSA-N

InChI

1S/C4HF6NO2/c5-3(6,7)1(12)11-2(13)4(8,9)10/h(H,11,12,13)

SMILES string

FC(F)(F)C(=O)NC(=O)C(F)(F)F

form

solid

mp

80-86 °C

functional group

amide
fluoro

Quality Level

Other Notes

Reagent for the trifluoroacetylation of amino-, hydroxy- and thiol-groups (useful for GLC and MS analyses).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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J Segura et al.
Journal of chromatography. B, Biomedical sciences and applications, 713(1), 61-90 (1998-08-13)
The development of low cost MS detectors in recent years has promoted an important increase in the applicability of GC-MS system to analyze for the presence of foreign substances in the human body. Drugs and toxic agents are in vivo
[Acylation with bis(acylamides). N-methyl-bis(trifluoroacetamide) and bis(trifluoroacetamide), two new reagents for trifluoroacetylation].
M Donike
Journal of chromatography, 78(2), 273-279 (1973-04-25)
Alex Siegel et al.
Journal of molecular biology, 432(24), 166708-166708 (2020-11-15)
The 43 kDa subunit of the chloroplast signal recognition particle, cpSRP43, is an ATP-independent chaperone essential for the biogenesis of the light harvesting chlorophyll-binding proteins (LHCP), the most abundant membrane protein family on earth. cpSRP43 is activated by a stromal factor
Jobst Liebau et al.
The Journal of biological chemistry, 295(29), 9868-9878 (2020-05-22)
Fold-switch pathways remodel the secondary structure topology of proteins in response to the cellular environment. It is a major challenge to understand the dynamics of these folding processes. Here, we conducted an in-depth analysis of the α-helix-to-β-strand and β-strand-to-α-helix transitions
Anette Kaiser et al.
Molecules (Basel, Switzerland), 25(20) (2020-10-21)
Many biological functions of peptides are mediated through G protein-coupled receptors (GPCRs). Upon ligand binding, GPCRs undergo conformational changes that facilitate the binding and activation of multiple effectors. GPCRs regulate nearly all physiological processes and are a favorite pharmacological target.

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