151564
5-Hydroxydopamine hydrochloride
98%
Synonym(s):
3,4,5-Trihydroxyphenethylamine hydrochloride
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About This Item
Linear Formula:
(HO)3C6H2CH2CH2NH2·HCl
CAS Number:
Molecular Weight:
205.64
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
227-223-8
MDL number:
Assay:
98%
Form:
powder
InChI key
WSZSSLCEWCKAKU-UHFFFAOYSA-N
InChI
1S/C8H11NO3.ClH/c9-2-1-5-3-6(10)8(12)7(11)4-5;/h3-4,10-12H,1-2,9H2;1H
SMILES string
Cl.NCCc1cc(O)c(O)c(O)c1
assay
98%
form
powder
mp
218-220 °C (lit.)
functional group
amine
Application
5-Hydroxydopamine hydrochloride was used in the preparation of hydrogen peroxide, superoxide radical and hydroxyl radical.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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E Kienzl et al.
Life sciences, 65(18-19), 1973-1976 (1999-11-27)
The mechanisms leading to degeneration of melanized dopaminergic neurons in the brain stem, and particularly in the substantia nigra zona compacta (SNZC) in patients with Parkinson's disease (PD) are still unknown. Demonstration of increased iron Fe(III) in SNZC of PD
Mikyung Shin et al.
Acta biomaterialia, 95, 165-175 (2018-10-27)
3D bioprinting is an attractive technique to fabricate well-organized, cell-laden constructs for tissue repair and disease modeling. Although numerous hydrogel bioinks have been developed, materials are still needed that mimic the cellular microenvironment, have the appropriate viscosity and stabilization for
J C Linder et al.
Neurochemistry international, 26(2), 195-202 (1995-02-01)
The dopaminergic projection from the substantia nigra to the neostriatum is vulnerable to several neurotoxins including 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), amphetamine, and 5-hydroxydopamine. We have treated rats or mice with these agents and examined various regions of their brains with a combination
K Jellinger et al.
Journal of neural transmission. Supplementum, 46, 297-314 (1995-01-01)
The presence of 5-Hydroxydopamine (5-OHDA) and 6-Hydroxydopamine (6-OHDA) in the urine of parkinsonian patients on levodopa medication was reported by Andrew et al. (1993). To answer the question about the putative relevance of 6-OHDA endogenously formed in the brain for
C Spenger et al.
Experimental brain research, 112(1), 47-57 (1996-11-01)
Free-floating roller tube cultures of human fetal (embryonic age 6-10 weeks post-conception) and rat fetal (embryonic day 13) ventral mesencephalon were prepared. After 7-15 days in vitro, the mesencephalic tissue cultures were transplanted into the striatum of adult rats that
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