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Key Documents

Safety Information

147516

Sigma-Aldrich

trans-1,2-Cyclohexanedicarboxylic acid

95%

Synonym(s):

trans-Cyclohexane-1,2-dicarboxylic acid, trans-Hexahydrophthalic acid

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About This Item

Linear Formula:
C6H10(CO2H)2
CAS Number:
Molecular Weight:
172.18
Beilstein:
3200609
EC Number:
MDL number:
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.23

Assay

95%

form

powder

mp

228-230 °C (lit.)

SMILES string

OC(=O)[C@@H]1CCCC[C@H]1C(O)=O

InChI

1S/C8H12O4/c9-7(10)5-3-1-2-4-6(5)8(11)12/h5-6H,1-4H2,(H,9,10)(H,11,12)/t5-,6-/m0/s1

InChI key

QSAWQNUELGIYBC-WDSKDSINSA-N

Other Notes

Remainder cis

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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B A Jönsson et al.
Scandinavian journal of work, environment & health, 19(3), 183-190 (1993-06-01)
Six healthy volunteers were exposed to gaseous hexahydrophthalic anhydride (HHPA) concentrations of 10, 40, or 80 micrograms.m-3 (65, 260 or 520 nmol.m-3, respectively) for 8 h. The respiratory uptake of the inhaled HHPA was almost complete. Rapid increases in plasma
B Jönsson et al.
Journal of chromatography, 572(1-2), 117-131 (1991-12-06)
A method for the determination of hexahydrophthalic acid, a metabolite of hexahydrophthalic anhydride, in human urine has been developed. The urine was worked-up by liquid-solid extraction, esterified with boron trifluoride-methanol, and analysed by capillary gas chromatography and selected-ion monitoring. Hexadeuterium-labelled
L C Grammer et al.
The Journal of laboratory and clinical medicine, 127(5), 443-447 (1996-05-01)
Occupational immunologic lung diseases caused by exposures to substances such as hexahydrophthalic anhydride are significant health problems. It would be useful to identify risk factors, other than exposure, for occupational immunologic lung diseases such as occupational asthma. Our objective was
B A Jönsson et al.
American Industrial Hygiene Association journal, 55(4), 330-338 (1994-04-01)
A method for generating controlled atmospheres of hexahydrophthalic anhydride (HHPA) in an 8 m3 exposure chamber was developed. The permeation principle was used for gaseous HHPA generation. HHPA concentration was monitored by sampling on XAD-2 tubes and by a Fourier-transform
B A Jönsson et al.
International archives of occupational and environmental health, 65(1), 43-47 (1993-01-01)
Urinary hexahydrophthalic acid (HHP acid) levels were determined in 20 workers occupationally exposed to hexahydrophthalic anhydride (HHPA) air levels of 11-220 micrograms/m3. The levels of HHP acid in urine increased rapidly during exposure and the decreases were also rapid after

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