141712
trans-1,2-Cyclohexanediol
98%
Synonym(s):
1,2-trans -Cyclohexanediol, 1,2-trans -Dihydroxycyclohexane, trans -2-Hydroxycyclohexanol
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About This Item
Linear Formula:
C6H10(OH)2
CAS Number:
Molecular Weight:
116.16
UNSPSC Code:
12162002
NACRES:
NA.23
PubChem Substance ID:
EC Number:
215-956-6
Beilstein/REAXYS Number:
3193810
MDL number:
InChI key
PFURGBBHAOXLIO-PHDIDXHHSA-N
InChI
1S/C6H12O2/c7-5-3-1-2-4-6(5)8/h5-8H,1-4H2/t5-,6-/m1/s1
SMILES string
O[C@@H]1CCCC[C@H]1O
assay
98%
form
solid
mp
101-104 °C (lit.)
Quality Level
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Related Categories
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Lisa D Cervia et al.
Molecular therapy. Nucleic acids, 11, 263-271 (2018-06-03)
The nuclear envelope is a physiological barrier to electrogene transfer. To understand different mechanisms of the nuclear entry for electrotransfected plasmid DNA (pDNA), the current study investigated how manipulation of the mechanisms could affect electrotransfection efficiency (eTE), transgene expression level
Ine Lentacker et al.
Journal of controlled release : official journal of the Controlled Release Society, 132(3), 279-288 (2008-07-29)
After administration to the body, nucleic acid containing nanoparticles (NANs) need to cross several extra- and intracellular barriers to reach the cytoplasm or nucleus of the target cells. In the last decade several groups tried to overcome these barriers by
Ivan Liashkovich et al.
Journal of controlled release : official journal of the Controlled Release Society, 160(3), 601-608 (2012-03-06)
The efficiency of gene therapy in non-dividing cells is particularly poor due to restricted nuclear delivery rates of exogenously applied macromolecules across the nuclear pore complexes (NPCs). Therefore, improved intranuclear delivery of transgenes requires an ability to modulate the barrier
T Kiguchi et al.
Chemical & pharmaceutical bulletin, 48(10), 1536-1540 (2000-10-25)
Asymmetric spirocyclization based on intramolecular conjugate addition using a combination of a Lewis acid and an optically active cyclohexane-1,2-diol has been studied in connection with 1) the effect of substituents on the cyclohexane-1,2-diol and 2) the effect of substituents on
Andreas Hartung et al.
The Journal of organic chemistry, 72(26), 10235-10238 (2007-11-16)
Comparison is made between the preparation of trans-1,2-cyclohexanediol in standard glassware (conventional batch production) and in a microreactor (continuous flow production). The reaction sequence involved two exothermic steps where the standard procedure demands slow reagent addition and careful temperature control.
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