14075
Succinic semialdehyde solution
~15% in H2O (T)
Synonym(s):
4-Oxobutanoic acid, 4-Oxobutyric acid, Succinaldehydic acid, Succinic semialdehyde monomer
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About This Item
Linear Formula:
HCOCH2CH2COOH
CAS Number:
Molecular Weight:
102.09
Beilstein:
1745187
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
Recommended Products
concentration
~15% in H2O (T)
storage temp.
2-8°C
SMILES string
OC(=O)CCC=O
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Other Notes
Enzyme-catalyzed aldol reaction with DHAP; Substrate for succinic semialdehyde dehydrogenase
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Berin A Boughton et al.
Proteins, 80(8), 2117-2122 (2012-05-04)
The crystal structure of Escherichia coli dihydrodipicolinate synthase with pyruvate and substrate analogue succinic acid semialdehyde condensed with the active site lysine-161 was solved to a resolution of 2.3 Å. Comparative analysis to a previously reported structure both resolves the
Luiz Pedro S de Carvalho et al.
Archives of biochemistry and biophysics, 509(1), 90-99 (2011-02-10)
Succinic semialdehyde dehydrogenases (SSADHs) are ubiquitous enzymes that catalyze the NAD(P)+-coupled oxidation of succinic semialdehyde (SSA) to succinate, the last step of the γ-aminobutyrate shunt. Mycobacterium tuberculosis encodes two paralogous SSADHs (gabD1 and gabD2). Here, we describe the first mechanistic
Hatice Gökcan et al.
The Journal of organic chemistry, 77(13), 5533-5543 (2012-06-01)
Pyridoxal 5-phosphate (PLP), the phosphorylated and the oxidized form of vitamin B6 is an organic cofactor. PLP forms a Schiff base with the ϵ-amino group of a lysine residue of PLP-dependent enzymes. γ-Aminobutyric acid (GABA) aminotransferase is a PLP-dependent enzyme
Hongzhi Tang et al.
The Journal of biological chemistry, 286(45), 39179-39187 (2011-09-29)
Nicotine, the main alkaloid produced by Nicotiana tabacum and other Solanaceae, is very toxic and may be a leading toxicant causing preventable disease and death, with the rise in global tobacco consumption. Several different microbial pathways of nicotine metabolism have
Jiri Brichac et al.
Chemical research in toxicology, 20(6), 887-895 (2007-05-08)
trans-4-Hydroxy-2-nonenal (HNE) is a cytotoxic alpha,beta-unsaturated aldehyde implicated in the pathology of multiple diseases involving oxidative damage. Oxidation of HNE by aldehyde dehydrogenases (ALDHs) to trans-4-hydroxy-2-nonenoic acid (HNEA) is a major route of metabolism in many organisms. HNE exists as
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