137111
Ethoxyacetic acid
98%
Synonym(s):
O-Ethylglycolic acid
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All Photos(2)
About This Item
Linear Formula:
C2H5OCH2COOH
CAS Number:
Molecular Weight:
104.10
Beilstein:
1743037
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Assay
98%
refractive index
n20/D 1.419 (lit.)
bp
97-100 °C/11 mmHg (lit.)
density
1.102 g/mL at 25 °C (lit.)
SMILES string
CCOCC(O)=O
InChI
1S/C4H8O3/c1-2-7-3-4(5)6/h2-3H2,1H3,(H,5,6)
InChI key
YZGQDNOIGFBYKF-UHFFFAOYSA-N
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General description
Ethoxyacetic acid is biomarker of exposure to widely used industrial chemicals such as alkyl-substituted ethylene glycols and other aliphatic ethers.
Application
Ethoxyacetic acid is metabolite of glycol ether alkoxy acid and was used to evaluate its toxicity in embryonic stem cell test in mouse. It was used in zebrafish embryotoxicity test to study chemical toxicity after exposure of the complete vertebrate embryo during embryogenesis in ovo.
Biochem/physiol Actions
Ethoxyacetic acid induces testicular toxicity in rats in vivo .
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
WGK
WGK 3
Flash Point(F)
206.6 °F
Flash Point(C)
97 °C
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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D Groeseneken et al.
International archives of occupational and environmental health, 61(4), 249-254 (1989-01-01)
A sensitive and specific method for the determination in urine of alkoxyacetic acids, the metabolites of ethylene glycol monoalkyl ethers, was developed by combining the advantages of two previously described methods. The acids were determined gas chromatographically as their pentafluorobenzylesters.
T Sakai et al.
International archives of occupational and environmental health, 64(7), 495-498 (1993-01-01)
In control subjects and workers exposed to glycol ethers and their acetates, we determined the urinary metabolites (three alkoxyacetic acids) by a simple and rapid method. Levels of urinary metabolites were significantly higher in the solvent workers than in the
J C Hoflack et al.
Mutation research, 341(4), 281-287 (1995-02-01)
Ethylene glycol ethers, their aldehyde and their acid metabolites were evaluated for their mutagenicity with the Ames test. The Salmonella typhimurium his- tester strains TA 97a, TA 98, TA 100 and TA 102 were used with and without rat S9
Esther de Jong et al.
Toxicological sciences : an official journal of the Society of Toxicology, 110(1), 117-124 (2009-04-30)
The embryonic stem cell test (EST) has been proposed as an in vitro assay that might reduce animal experimentation in regulatory developmental toxicology. So far, evaluation of the EST was not performed using compounds within distinct chemical classes. Evaluation within
L Aasmoe et al.
Xenobiotica; the fate of foreign compounds in biological systems, 27(12), 1237-1244 (1998-02-14)
1. The elimination of 2-methoxyethanol (2-ME) and its toxic metabolite methoxyacetic acid (MAA) was studied in the male and female rat. We also studied the elimination of ethoxyacetic acid (EAA), the toxic metabolite formed by 2-ethoxyethanol (2-EE). 2. The rate
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