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135690

Sigma-Aldrich

3,5-Diisopropyl-2-hydroxybenzoic acid

98%

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Synonym(s):
3,5-Diisopropylsalicylic acid
Linear Formula:
[(CH3)2CH]2C6H2-2-(OH)CO2H
CAS Number:
Molecular Weight:
222.28
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Assay

98%

form

powder

mp

113-115 °C (lit.)

SMILES string

CC(C)c1cc(C(C)C)c(O)c(c1)C(O)=O

InChI

1S/C13H18O3/c1-7(2)9-5-10(8(3)4)12(14)11(6-9)13(15)16/h5-8,14H,1-4H3,(H,15,16)

InChI key

XUFUYOGWFZSHGE-UHFFFAOYSA-N

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General description

3,5-Diisopropyl-2-hydroxybenzoic acid plays the role of OH-inactivating ligand in its complexes with copper(II).

Application

3,5-Diisopropyl-2-hydroxybenzoic acid was used as starting reagent in the synthesis of Zn(II) and Cd(II) carboxylate complexes.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Monika Homoncik et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 14(2), 131-138 (2003-03-13)
We examined the influence of 3,5-diisopropylsalicylic acid (3,5-DIPS) and calcium(II)3 (3,5-diisopropylsalicylate)6 (H2 O)6 [Ca(II)3 (3,5-DIPS)6 ], a new activator of calcium-dependent calmodulin-triggered nitric oxide synthase, on thrombin-induced platelet P-selectin expression. Citrated whole blood samples were incubated with either ethanol vehicle
Eugene O Apostolov et al.
Radiation research, 172(4), 481-492 (2009-09-24)
Gamma radiation is known to induce cell death in several organs. This damage is associated with endonuclease-mediated DNA fragmentation; however, the enzyme that produces the latter and is likely to cause cell death is unknown. To determine whether the most
L F Charles et al.
Journal of materials science. Materials in medicine, 21(6), 1845-1854 (2010-03-20)
Currently, the bone-repair biomaterials market is dominated by high modulus metals and their alloys. The problem of stress-shielding, which results from elastic modulus mismatch between these metallic materials and natural bone, has stimulated increasing research into the development of polymer-ceramic
V Brumas et al.
Journal of inorganic biochemistry, 101(4), 565-577 (2007-01-20)
The purpose of this study was to identify the low molecular mass complexes formed between copper(II) and 3,5-diisopropylsalicylic acid (Dips) in physiological conditions. Copper(II)-Dips complex equilibria were determined using glass electrode potentiometry and their solution structures checked by UV-visible (UV-vis)
Yao Yu et al.
European journal of medicinal chemistry, 43(7), 1438-1443 (2007-10-26)
Novel lipophilic platinum(II) complexes (LSPt-1-3), containing 3,5-diisopropylsalicylate (DIPS) as a leaving group and 2NH(3) or 1R,2R-diaminocyclohexane or (4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane as the carrier, have been synthesized, characterized and evaluated in vitro and in vivo. The octanol/water distribution coefficient of the complexes has

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