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Safety Information

135380

Sigma-Aldrich

Phenylacetone

99%

Synonym(s):

Benzyl methyl ketone, Phenyl-2-propanone

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About This Item

Linear Formula:
C6H5CH2COCH3
CAS Number:
Molecular Weight:
134.18
Beilstein:
742120
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:

Assay

99%

form

liquid

drug control

USDEA Schedule II

availability

available only in EU

density

1.003 g/mL at 20 °C (lit.)

SMILES string

CC(=O)Cc1ccccc1

InChI

1S/C9H10O/c1-8(10)7-9-5-3-2-4-6-9/h2-6H,7H2,1H3

InChI key

QCCDLTOVEPVEJK-UHFFFAOYSA-N

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General description

Phenylacetone is the immediate precursor for clandestine production of amphetamine and methamphetamine. Phenylacetone on anaerobic incubations with rat liver mitochondria gets reduced to phenylisopropanol.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

194.0 °F - closed cup

Flash Point(C)

90 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Sudaporn Wongwan et al.
Electrophoresis, 31(9), 1475-1481 (2010-04-02)
A CE assay for the simultaneous determination of charged and uncharged potential impurities (1S,2S-(+)-norpseudoephedrine, 1R,2S-(-)-norephedrine, phenylacetone and phenylacetone oxime) of dexamphetamine sulfate including the stereoisomer levoamphetamine was developed and validated. The optimized background electrolyte consisted of a 50 mM sodium
Pushkar Shejwalkar et al.
Molecules (Basel, Switzerland), 15(4), 2631-2650 (2010-04-30)
New phosphoramidite complexes of iron were synthesized and structurally characterized. Reaction of the known chiral phosphoramidites (RO)2PNR'2 (R = binaphthyl, R' = CH3, 1a; R = binaphthyl, R' = benzyl, 1b) with [FeBr(Cp)(CO)2] afforded the title compounds [FeBr(Cp)(CO)(1a,b)] (4a,b) in
Hugo L van Beek et al.
Chemical communications (Cambridge, England), 48(27), 3288-3290 (2012-01-31)
The thermostable Baeyer-Villiger monooxygenase (BVMO) phenylacetone monooxygenase (PAMO) is used as a scaffold to introduce novel selectivities from other BVMOs or the metagenome by structure-inspired subdomain exchanges. This yields biocatalysts with new preferences in the oxidation of sulfides and the
Stefano Franceschini et al.
The Journal of biological chemistry, 287(27), 22626-22634 (2012-05-19)
Steroid monooxygenase (STMO) from Rhodococcus rhodochrous catalyzes the Baeyer-Villiger conversion of progesterone into progesterone acetate using FAD as prosthetic group and NADPH as reducing cofactor. The enzyme shares high sequence similarity with well characterized Baeyer-Villiger monooxygenases, including phenylacetone monooxygenase and
C E Green et al.
The Journal of pharmacology and experimental therapeutics, 237(3), 931-936 (1986-06-01)
Isolated hepatocyte suspensions from rat, rabbit, dog, squirrel monkey and human livers were used to study the metabolism of amphetamine (AMP), a drug for which species-dependent differences in metabolism have been demonstrated in vivo. Hepatocytes were isolated by perfusion of

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