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129925

Sigma-Aldrich

Methyl methanesulfonate

99%

Synonym(s):

Methanesulfonic acid methyl ester

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About This Item

Linear Formula:
CH3SO3CH3
CAS Number:
66-27-3
Molecular Weight:
110.13
Beilstein:
1098586
EC Number:
200-625-0
MDL number:
MFCD00007557
UNSPSC Code:
12352103
PubChem Substance ID:
24847934
NACRES:
NA.22

Quality Level

100

Assay

99%

form

liquid

refractive index

n20/D 1.414 (lit.)

bp

202-203 °C (lit.)

density

1.3 g/mL at 25 °C (lit.)

SMILES string

COS(C)(=O)=O

InChI

1S/C2H6O3S/c1-5-6(2,3)4/h1-2H3

InChI key

MBABOKRGFJTBAE-UHFFFAOYSA-N

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Principle

DNA adduct; adds methyl groups to DNA at 7-guanine preferentially, but also 3-adenine and 3-guanine.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 2 - Carc. 2 - Eye Irrit. 2 - Muta. 1B - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Inhalation

Target Organs

Lungs

WGK

WGK 3

Flash Point(F)

closed cup

Flash Point(C)

closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Dongqing Huang et al.
Molecular and cellular biology, 33(8), 1515-1527 (2013-02-06)
Cells employ error-free or error-prone postreplication repair (PRR) processes to tolerate DNA damage. Here, we present a genome-wide screen for sensitivity to 0.001% methyl methanesulfonate (MMS). This relatively low dose is of particular interest because wild-type cells exhibit no discernible
Cathrine Broberg Vågbø et al.
DNA repair, 12(3), 188-195 (2013-01-02)
Cytotoxic 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) lesions induced in DNA and RNA in vitro and in pre-damaged DNA and RNA bacteriophages in vivo are repaired by the Escherichia coli (E. coli) protein AlkB and a human homolog, ALKBH3. However, it
Stephen Godin et al.
Nucleic acids research, 41(8), 4525-4534 (2013-03-06)
The Saccharomyces cerevisiae Shu complex, consisting of Shu1, Shu2, Csm2 and Psy3, promotes error-free homologous recombination (HR) by an unknown mechanism. Recent structural analysis of two Shu proteins, Csm2 and Psy3, has revealed that these proteins are Rad51 paralogues and
Amaya Azqueta et al.
Toxicology in vitro : an international journal published in association with BIBRA, 27(2), 768-773 (2012-12-25)
A serious limitation of the conventional comet assay (single cell gel electrophoresis) is the restriction on the number of samples that can be processed in one experiment, imposed by the size of the electrophoresis platform. One approach to increasing throughput
Barbara van Loon et al.
DNA repair, 12(3), 177-187 (2013-01-08)
Due to a harsh environment mitochondrial genomes accumulate high levels of DNA damage, in particular oxidation, hydrolytic deamination, and alkylation adducts. While repair of alkylated bases in nuclear DNA has been explored in detail, much less is known about the
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