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128201

Sigma-Aldrich

N-Ethyl-o-crotonotoluidide

97%

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Synonym(s):
N-Ethyl-N-(2-methylphenyl)-2-butenamide, Crotamiton
Linear Formula:
CH3CH=CHCON(C2H5)C6H4CH3
CAS Number:
483-63-6
Molecular Weight:
203.28
EC Number:
207-596-3
MDL number:
MFCD00026989
UNSPSC Code:
12352100
PubChem Substance ID:
24847834
NACRES:
NA.22

description

predominantly trans

Quality Level

100

Assay

97%

form

solid

refractive index

n20/D 1.54 (lit.)

bp

153-155 °C/13 mmHg (lit.)

solubility

ethanol: soluble
methanol: soluble

density

0.987 g/mL at 25 °C (lit.)

SMILES string

CCN(C(=O)\C=C\C)c1ccccc1C

InChI

1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+

InChI key

DNTGGZPQPQTDQF-XBXARRHUSA-N

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Application

N-Ethyl-o-crotonotoluidide ( Crotamiton) was used to study the photocatalytic decomposition of crotamiton in aqueous solution using TiO2.
N-Ethyl-o-crotonotoluidide (Crotamiton) was used to treat scabies and various pruritic dermatoses.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 1

Flash Point(F)

235.4 °F

Flash Point(C)

113 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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The use of N-ethyl-o-crotonotoluidide in the treatment of scabies and various pruritic dermatoses.
M COUPERUS
The Journal of investigative dermatology, 13(1), 35-42 (1949-07-01)
F Forton et al.
The British journal of dermatology, 138(3), 461-466 (1998-05-15)
A standardized skin surface biopsy was performed in 34 patients suffering from skin diseases with high Demodex folliculorum density (Dd) > 5D/cm2 before, during and after topical treatment. The patients were randomized into six comparable groups to study six topical
Habib Ansarin et al.
Dermatology online journal, 12(1), 19-19 (2006-04-28)
A wide range of clinical manifestations may be seen in scabies, from classic pruritic papules and burrows to secondary features such as impetigo. Bullus lesions are a less frequent. Twenty cases of scabies presenting with bullae have been reported so
Ahmed M Al-Arfaj et al.
The American journal of tropical medicine and hygiene, 76(5), 967-971 (2007-05-10)
A 31-year-old Saudi man was seen at an ear, nose, and throat clinic at Riyadh, Saudi Arabia, with bilateral itching in the external auditory canal. On otoscopic examination, the skin lining the ear canal was thickened with whitish sheets of
N Nakada et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 61(7), 1739-1747 (2010-04-08)
The behavior of antibacterial triclosan, insect-repellent diethyltoluamide (DEET), anticonvulsant carbamazepine, and antipruritic crotamiton was investigated at two sewage treatment plants (STPs) to clarify their complete mass balance. Twenty-four-hour flow-proportional composite samples were collected from the influent and effluent of primary
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