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Merck
CN

128201

N-Ethyl-o-crotonotoluidide

97%

Synonym(s):

N-Ethyl-N-(2-methylphenyl)-2-butenamide, Crotamiton

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About This Item

Linear Formula:
CH3CH=CHCON(C2H5)C6H4CH3
CAS Number:
483-63-6
Molecular Weight:
203.28
NACRES:
NA.22
PubChem Substance ID:
24847834
UNSPSC Code:
12352100
EC Number:
207-596-3
MDL number:
MFCD00026989
Assay:
97%
Form:
solid

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InChI key

DNTGGZPQPQTDQF-XBXARRHUSA-N

InChI

1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+

SMILES string

CCN(C(=O)\C=C\C)c1ccccc1C

description

predominantly trans

assay

97%

form

solid

refractive index

n20/D 1.54 (lit.)

bp

153-155 °C/13 mmHg (lit.)

solubility

ethanol: soluble, methanol: soluble

density

0.987 g/mL at 25 °C (lit.)

Quality Level

100

Related Categories

Application

N-Ethyl-o-crotonotoluidide ( Crotamiton) was used to study the photocatalytic decomposition of crotamiton in aqueous solution using TiO2.
N-Ethyl-o-crotonotoluidide (Crotamiton) was used to treat scabies and various pruritic dermatoses.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
12204EU
10402BN
06028AW
04727CZ
35705DN

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The use of N-ethyl-o-crotonotoluidide in the treatment of scabies and various pruritic dermatoses.
M COUPERUS
The Journal of investigative dermatology, 13(1), 35-42 (1949-07-01)
Ahmed M Al-Arfaj et al.
The American journal of tropical medicine and hygiene, 76(5), 967-971 (2007-05-10)
A 31-year-old Saudi man was seen at an ear, nose, and throat clinic at Riyadh, Saudi Arabia, with bilateral itching in the external auditory canal. On otoscopic examination, the skin lining the ear canal was thickened with whitish sheets of
F Forton et al.
The British journal of dermatology, 138(3), 461-466 (1998-05-15)
A standardized skin surface biopsy was performed in 34 patients suffering from skin diseases with high Demodex folliculorum density (Dd) > 5D/cm2 before, during and after topical treatment. The patients were randomized into six comparable groups to study six topical
Habib Ansarin et al.
Dermatology online journal, 12(1), 19-19 (2006-04-28)
A wide range of clinical manifestations may be seen in scabies, from classic pruritic papules and burrows to secondary features such as impetigo. Bullus lesions are a less frequent. Twenty cases of scabies presenting with bullae have been reported so
Ulrich R Hengge et al.
The Lancet. Infectious diseases, 6(12), 769-779 (2006-11-25)
Scabies has been a scourge among human beings for thousands of years. Its worldwide occurrence with epidemics during war, famine, and overcrowding is responsible for an estimated 300 million people currently infested. Scabies refers to the various skin lesions produced
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