All Photos(3)
Synonym(s):
(3-Fluorophenyl)methanamine, 1-(3-Fluorophenyl)methanamine, 3-Fluorobenzenemethanamine, 3-Fluorophenylmethylamine, m-Fluorobenzylamine
Linear Formula:
FC6H4CH2NH2
CAS Number:
Molecular Weight:
125.14
EC Number:
MDL number:
UNSPSC Code:
12352100
eCl@ss:
39040408
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
Quality Level
Assay
97%
form
liquid
refractive index
n20/D 1.514 (lit.)
density
1.097 g/mL at 25 °C (lit.)
SMILES string
NCc1cccc(F)c1
InChI
1S/C7H8FN/c8-7-3-1-2-6(4-7)5-9/h1-4H,5,9H2
InChI key
QVSVMNXRLWSNGS-UHFFFAOYSA-N
Application
3-Fluorobenzylamine has been used to study the rate of reaction of benzylamines with 1-Chloro-2,4-dinitrobenzene and toluene-p-sulphonyl chloride. It has also been used in the synthesis of substituted amino-sulfonamide protease inhibitors (PIs) DPC 681 and DPC 684.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Skin Corr. 1B
WGK
WGK 3
Flash Point(F)
159.8 °F
Flash Point(C)
71 °C
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Fischer A, et al.
Journal of the Chemical Society B: Physical Organic, 466-468 (1966)
A Paden King et al.
Dalton transactions (Cambridge, England : 2003), 48(18), 5987-6002 (2019-01-24)
Four cobalt(iii) complexes of the general formula [Co(Schiff base)(L)2]+, where L is ammonia (NH3) or 3-fluorobenzylamine (3F-BnNH2), were synthesized. The complexes were characterized by NMR spectroscopy, mass spectrometry, and X-ray crystallography. Their electrochemical properties, ligand substitution mechanisms, and ligand exchange
Hua-Li Yang et al.
European journal of medicinal chemistry, 138, 715-728 (2017-07-21)
A series of coumarin-pargyline hybrids (4a-x) have been designed, synthesized and evaluated as novel dual inhibitors of Alzheimer's disease (AD). Most of the compounds exhibited a potent ability to inhibit amyloid-β (Aβ) aggregation and monoamine oxidases. In particular, compound 4x
R F Kaltenbach et al.
Antimicrobial agents and chemotherapy, 45(11), 3021-3028 (2001-10-16)
Human immunodeficiency virus (HIV) protease inhibitors (PIs) are important components of many highly active antiretroviral therapy regimens. However, development of phenotypic and/or genotypic resistance can occur, including cross-resistance to other PIs. Development of resistance takes place because trough levels of
Simon H Rüdisser et al.
Journal of biomolecular NMR, 74(10-11), 579-594 (2020-06-20)
Fluorine NMR has recently gained high popularity in drug discovery as it allows efficient and sensitive screening of large numbers of ligands. However, the positive hits found in screening must subsequently be ranked according to their affinity in order to
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