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Safety Information

125172

Sigma-Aldrich

4-Chloro-1,3-diaminobenzene

97%

Synonym(s):

4-Chloro-1,3-phenylenediamine

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About This Item

Linear Formula:
ClC6H3(NH2)2
CAS Number:
5131-60-2
Molecular Weight:
142.59
EC Number:
225-877-9
MDL number:
MFCD00025284
UNSPSC Code:
12352100
PubChem Substance ID:
24847651
NACRES:
NA.22

Assay

97%

mp

87-90 °C (lit.)

functional group

chloro

SMILES string

Nc1ccc(Cl)c(N)c1

InChI

1S/C6H7ClN2/c7-5-2-1-4(8)3-6(5)9/h1-3H,8-9H2

InChI key

ZWUBBMDHSZDNTA-UHFFFAOYSA-N

General description

4-Chloro-1,3-diaminobenzene is dye precursor useful in manufacture of hair dyes.

Application

4-Chloro-1,3-diaminobenzene has been used to study the mutagenic effect of phenylenediamines hair chemicals on Salmonella typhimurium TA 102.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
16210PD
04521MU

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Charity Mosley-Foreman et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 46(12), 3780-3784 (2008-10-23)
Phenylenediamines (PD) are dye precursors used to manufacture hair dyes. The three PDs, 1,2-,1,3-, and 1,4-PD and three chlorinated PDs, 4-chloro-1,2-PD, 4-chloro-1,3-PD, and 4,5-dichloro-1,2-PD were studied for their mutagenic effect in Salmonella typhimurium TA 102, cytotoxicity in human skin keratinocyte
4-Chloro-ortho-phenylenediamine and 4-chloro-meta-phenylenediamine.
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 27, 81-89 (1982-04-01)
E K Weisburger et al.
Carcinogenesis, 1(6), 495-499 (1980-06-01)
In both male and female Fischer rats, feeding 4-chloro-o-phenylenediamine at 0.5 or 1% in the diet led to a significant increase in hyperplasia, papilloma and carcinoma of the urinary bladder. Neoplastic nodules of the liver and squamous cell papillomas of

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