123129
2-Aminothiazole
97%
Synonym(s):
2-Thiazolamine
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About This Item
Empirical Formula (Hill Notation):
C3H4N2S
CAS Number:
Molecular Weight:
100.14
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
202-511-6
Beilstein/REAXYS Number:
105738
MDL number:
Product Name
2-Aminothiazole, 97%
InChI
1S/C3H4N2S/c4-3-5-1-2-6-3/h1-2H,(H2,4,5)
InChI key
RAIPHJJURHTUIC-UHFFFAOYSA-N
SMILES string
Nc1nccs1
assay
97%
mp
91-93 °C (lit.)
solubility
1 M HCl: soluble 50 mg/mL, clear (dark yellow-brown)
Quality Level
Application
2-Aminothiazole was used in the synthesis of 2-aminothiazole-modified silica gel. It was used in Ulmann coupling with 2-chlorobenzoic acids mediated by ultrasonic irradiation.
Biochem/physiol Actions
2-Aminothiazoles are potent cyclin-dependent kinase 5 inhibitors and are therapeutic agents for the treatment of Alzheimer′s disease and other neurodegenerative disorders.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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P S Roldan et al.
Analytical and bioanalytical chemistry, 375(4), 574-577 (2003-03-01)
This work describes the synthesis and characterization of 2-aminothiazole-modified silica gel (SiAT), as well as its application for preconcentration (in batch and column technique) of Cu(II), Ni(II) and Zn(II) in ethanol medium. The adsorption capacities of SiAT determined for each
Christopher J Helal et al.
Bioorganic & medicinal chemistry letters, 14(22), 5521-5525 (2004-10-16)
High-throughput screening with cyclin-dependent kinase 5 (cdk5)/p25 led to the discovery of N-(5-isopropyl-thiazol-2-yl)isobutyramide (1). This compound is an equipotent inhibitor of cdk5 and cyclin-dependent kinase 2 (cdk2)/cyclin E (IC(50)=ca. 320nM). Parallel and directed synthesis techniques were utilized to explore the
Synthetic Communications, 37, 1853-1853 (2007)
Xin Cao et al.
Bioorganic & medicinal chemistry, 16(11), 5890-5898 (2008-05-20)
Because both c-Src and iNOS are key regulatory enzymes in tumorigenesis, a new series of 4-heteroarylamino-3-quinolinecarbonitriles as potent dual inhibitors of both enzymes were designed, prepared, and evaluated for blocking multiple signaling pathways in cancer therapy. All compounds were evaluated
Breland Smith et al.
Bioorganic & medicinal chemistry letters, 22(10), 3567-3570 (2012-04-21)
This Letter presents the synthesis and biological evaluation of a collection of 2-aminothiazoles as a novel class of compounds with the capability to reduce the production of PGE(2) in HCA-7 human adenocarcinoma cells. A total of 36 analogs were synthesized
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