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Merck
CN

120693

α-Methyl-DL-tyrosine

98%

Synonym(s):

DL-2-Methyl-3-(4-hydroxyphenyl)alanine, AMPT

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About This Item

Linear Formula:
4-(HO)C6H4CH2C(CH3)(NH2)CO2H
CAS Number:
Molecular Weight:
195.22
EC Number:
211-523-0
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
2938704
MDL number:
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InChI key

NHTGHBARYWONDQ-UHFFFAOYSA-N

InChI

1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)

SMILES string

CC(N)(Cc1ccc(O)cc1)C(O)=O

assay

98%

form

powder

reaction suitability

reaction type: solution phase peptide synthesis

technique(s)

HPLC: suitable

color

white to off-white

mp

>300 °C (lit.)

application(s)

peptide synthesis

Gene Information

human ... TH(7054)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Joram D Mul et al.
PloS one, 8(3), e60214-e60214 (2013-04-05)
The orexigenic neuropeptide melanin-concentrating hormone (MCH), a product of Pmch, is an important mediator of energy homeostasis. Pmch-deficient rodents are lean and smaller, characterized by lower food intake, body-, and fat mass. Pmch is expressed in hypothalamic neurons that ultimately
Sunhoe Bang et al.
PLoS genetics, 7(3), e1001346-e1001346 (2011-04-02)
The ability to respond to environmental temperature variation is essential for survival in animals. Flies show robust temperature-preference behaviour (TPB) to find optimal temperatures. Recently, we have shown that Drosophila mushroom body (MB) functions as a center controlling TPB. However
Khoa D Nguyen et al.
Nature, 480(7375), 104-108 (2011-11-22)
All homeotherms use thermogenesis to maintain their core body temperature, ensuring that cellular functions and physiological processes can continue in cold environments. In the prevailing model of thermogenesis, when the hypothalamus senses cold temperatures it triggers sympathetic discharge, resulting in
Maria Xilouri et al.
PloS one, 4(5), e5515-e5515 (2009-05-14)
The mechanisms through which aberrant alpha-synuclein (ASYN) leads to neuronal death in Parkinson's disease (PD) are uncertain. In isolated liver lysosomes, mutant ASYNs impair Chaperone Mediated Autophagy (CMA), a targeted lysosomal degradation pathway; however, whether this occurs in a cellular
Breg Braak et al.
European journal of nuclear medicine and molecular imaging, 39(4), 642-650 (2011-12-14)
Functional dyspepsia (FD) is a chronic condition characterized by upper abdominal symptoms without an identifiable cause. While the serotonergic system is thought to play a key role in the regulation of gut physiology, the role of the dopaminergic system, which

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