10924
Sodium cyclohexanesulfonate
≥98.0% (T)
Synonym(s):
Cyclohexanesulfonic acid sodium salt
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About This Item
Empirical Formula (Hill Notation):
C6H11NaO3S
CAS Number:
Molecular Weight:
186.20
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
≥98.0% (T)
Form:
solid
InChI
1S/C6H12O3S.Na/c7-10(8,9)6-4-2-1-3-5-6;/h6H,1-5H2,(H,7,8,9);/q;+1/p-1
SMILES string
[Na+].[O-]S(=O)(=O)C1CCCCC1
InChI key
DIIKAKPJAGLSOD-UHFFFAOYSA-M
assay
≥98.0% (T)
form
solid
impurities
≤1% water
General description
Sodium cyclohexanesulfonate is a white to faintly beige powder to fine crystals with lump.
Application
Sodium cyclohexanesulfonate was used to study the influence of various hydrophobic ionic excipients on viscosity of concentrated solutions of therapeutic proteins. It was used as an ionic hydrophobic excipient that substantially decrease the viscosity of concentrated (300-400 mg/mL) aqueous solutions of bovine serum albumin and γ-globulin.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Wei Du et al.
Biotechnology and bioengineering, 108(3), 632-636 (2011-01-20)
Reducing viscosities of concentrated solutions of therapeutic proteins is important for their subcutaneous and intravenous delivery. Although inorganic salts and optimizing the pH were previously reported to dramatically lower the viscosity of a monoclonal antibody solution, herein we have determined
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